Single Cell Omics: From Assay Design to Biomedical Application
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DOI: 10.1002/biot.201900262
Abstract: Given the existence of cell heterogeneity, single cell analysis is undergoing a rapid expansion for life science and precision medicine. Recent numerous innovations in analytical platforms and instruments have re‐energized the field and led to… read more here.
Keywords: single cell; design biomedical; assay design; omics assay ... See more keywords
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity
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DOI: 10.1007/s00204-017-2041-7
Abstract: Lars Kuepfer1 · Olivia Clayton2 · Christoph Thiel1 · Henrik Cordes1 · Ramona Nudischer2 · Lars M. Blank1 · Vanessa Baier1 · Stephane Heymans3,4 · Florian Caiment5 · Adrian Roth2 · David A. Fluri6 ·… read more here.
Keywords: model based; design reproduce; assay design; vivo patterns ... See more keywords
Assay design for unambiguous identification and quantification of circulating pathogen-derived peptide biomarkers
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DOI: 10.7150/thno.70373
Abstract: Rationale: Circulating pathogen-derived proteins can serve as useful biomarkers for infections but may be detected with poor sensitivity and specificity by standard immunoassays due to masking effects and cross-reactivity. Mass spectrometry (MS)-read immunoassays for biomarker-derived… read more here.
Keywords: tuberculosis; disease; circulating pathogen; pathogen derived ... See more keywords