Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion
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DOI: 10.1016/j.isci.2019.01.018
Abstract: Summary We identified ∼30-mer amyloid-β protein (Aβ) assemblies, termed amylospheroids, from brains of patients with Alzheimer disease (AD) as toxic entities responsible for neurodegeneration and showed that Na+,K+-ATPase α3 (NAKα3) is the sole target of… read more here.
Keywords: excitatory neurons; proteasome inhibition; assemblies accumulate; accumulate excitatory ... See more keywords