Engineering Self-Assembling Protein Nanoparticles for Therapeutic Delivery
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate Chemistry"
DOI: 10.1021/acs.bioconjchem.2c00030
Abstract: Despite remarkable advances over the past several decades, many therapeutic nanomaterials fail to overcome major in vivo delivery barriers. Controlling immunogenicity, optimizing biodistribution, and engineering environmental responsiveness are key outstanding delivery problems for most nanotherapeutics.… read more here.
Keywords: therapeutic delivery; assembling protein; protein nanoparticles; self assembling ... See more keywords
Classification of self-assembling protein nanoparticle architectures for applications in vaccine design
Sign Up to like & getrecommendations! Published in 2017 at "Royal Society Open Science"
DOI: 10.1098/rsos.161092
Abstract: We introduce here a mathematical procedure for the structural classification of a specific class of self-assembling protein nanoparticles (SAPNs) that are used as a platform for repetitive antigen display systems. These SAPNs have distinctive geometries… read more here.
Keywords: classification; self assembling; vaccine design; assembling protein ... See more keywords
Design and development of a self-assembling protein nanoparticle displaying PfHAP2 antigenic determinants recognized by natural acquired antibodies
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0274275
Abstract: Backgrounds In order to move towards the elimination and eradication of malaria in the world, the development of vaccines is inevitable. Many modern vaccines are based on recombinant technology; however, they may not provide a… read more here.
Keywords: development; assembling protein; sapn; design ... See more keywords
Self-Assembling Protein Surfaces for In Situ Capture of Cell-Free-Synthesized Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.915035
Abstract: We present a new method for the surface capture of proteins in cell-free protein synthesis (CFPS). We demonstrate the spontaneous self-assembly of the protein BslA into functionalizable surfaces on the surface of a CFPS reaction… read more here.
Keywords: cell free; assembling protein; protein surfaces; surfaces situ ... See more keywords
Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15010231
Abstract: Targeted nanoparticles of different origins are considered as new-generation diagnostic and therapeutic tools. However, there are no targeted drug formulations within the composition of nanoparticles approved by the FDA for use in the clinic, which… read more here.
Keywords: assembling protein; protein nanoparticles; protein; self assembling ... See more keywords
Orientation of Antigen Display on Self-Assembling Protein Nanoparticles Influences Immunogenicity
Sign Up to like & getrecommendations! Published in 2021 at "Vaccines"
DOI: 10.3390/vaccines9020103
Abstract: Self-assembling protein nanoparticles (SAPN) serve as a repetitive antigen delivery platform with high-density epitope display; however, antigen characteristics such as size and epitope presentation can influence the immunogenicity of the assembled particle and are aspects… read more here.
Keywords: immunogenicity; self assembling; assembling protein; display ... See more keywords