Novel aspects of the assembly and activation of inflammasomes with focus on the NLRC4 inflammasome
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DOI: 10.1093/intimm/dxy009
Abstract: Inflammasomes are multiprotein structures that activate caspase-1, support secretion of pro-inflammatory cytokines, IL-1β and IL-18, and also induce inflammatory programmed cell death, termed pyoptosis. Inflammasomes are activated in response to the detection of endogenous and… read more here.
Keywords: novel aspects; aspects assembly; inflammasomes focus; focus nlrc4 ... See more keywords
Structural insights into the assembly and activation of the IL‐27 signaling complex
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DOI: 10.15252/embr.202255450
Abstract: Interleukin 27 (IL‐27) is a heterodimeric cytokine that elicits potent immunosuppressive responses. Comprised of EBI3 and p28 subunits, IL‐27 binds GP130 and IL‐27Rα receptor chains to activate the JAK/STAT signaling cascade. However, how these receptors… read more here.
Keywords: cytokine; structural insights; assembly activation; signaling complex ... See more keywords