Nonlinear Biosynthetic Assembly of Alpiniamide by a Hybrid cis/trans-AT PKS-NRPS.
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DOI: 10.1021/acschembio.0c00081
Abstract: Alpiniamide A is a linear polyketide produced by Streptomyces endophytic bacteria. Despite its relatively simple chemical structure suggestive of a linear assembly line biosynthetic construction involving a hybrid polyketide synthase-nonribosomal peptide synthetase enzymatic protein machine,… read more here.
Keywords: pks nrps; biosynthetic assembly; nonlinear biosynthetic; assembly alpiniamide ... See more keywords