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   Articles with "assembly checkpoint" as a keyword



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An Attachment-Independent Biochemical Timer of the Spindle Assembly Checkpoint.

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recommendations! Published in 2017 at "Molecular cell"

DOI: 10.1016/j.molcel.2017.10.011

Abstract: The spindle assembly checkpoint (SAC) generates a diffusible protein complex that prevents anaphase until all chromosomes are properly attached to spindle microtubules. A key step in SAC initiation is the recruitment of MAD1 to kinetochores,… read more here.

Keywords: attachment independent; spindle assembly; timer; biochemical timer ... See more keywords

The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment

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recommendations! Published in 2017 at "Stem Cell Reports"

DOI: 10.1016/j.stemcr.2017.09.017

Abstract: Summary The spindle assembly checkpoint plays a pivotal role in preventing aneuploidy and transformation. Many studies demonstrate impairment of this checkpoint in cancer cells. While leukemia is frequently driven by transformed hematopoietic stem and progenitor… read more here.

Keywords: spindle assembly; engraftment; checkpoint; progenitor ... See more keywords

The long noncoding RNA CRYBG3 induces aneuploidy by interfering with spindle assembly checkpoint via direct binding with Bub3

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recommendations! Published in 2021 at "Oncogene"

DOI: 10.1038/s41388-020-01601-8

Abstract: Aneuploidy is a hallmark of genomic instability that leads to tumor initiation, progression, and metastasis. CDC20, Bub1, and Bub3 form the mitosis checkpoint complex (MCC) that binds the anaphase-promoting complex or cyclosome (APC/C), a crucial… read more here.

Keywords: spindle assembly; crybg3; lnc crybg3; bub3 ... See more keywords

Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-08957-w

Abstract: Animal cells undergo rapid rounding during mitosis, ensuring proper chromosome segregation, during which an outward rounding force abruptly increases upon prometaphase entry and is maintained at a constant level during metaphase. Initial cortical tension is… read more here.

Keywords: cortical tension; spindle assembly; cdk1 mediated; tension ... See more keywords

A coadapted KNL1 and spindle assembly checkpoint axis orchestrates precise mitosis in Arabidopsis

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2316583121

Abstract: Significance As a scaffold for kinetochore assembly, kinetochore scaffold 1 (KNL1) functions in recruiting spindle assembly checkpoint (SAC) components among many well-studied eukaryotes from yeasts to humans. Plants have acquired many unique features associated with… read more here.

Keywords: assembly checkpoint; mitosis; spindle assembly; checkpoint ... See more keywords

The Arabidopsis BUB1/MAD3 family protein BMF3 requires BUB3.3 to recruit CDC20 to kinetochores in spindle assembly checkpoint signaling

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2322677121

Abstract: Significance Mitotic progression into anaphase is monitored by the spindle assembly checkpoint that is poorly understood in plants. Using Arabidopsis thaliana as a model system, we identified an interaction pattern centered at the BUB1 and… read more here.

Keywords: family protein; bub1 mad3; protein bmf3; assembly checkpoint ... See more keywords
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Bub1 kinase in the regulation of mitosis

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recommendations! Published in 2021 at "Animal Cells and Systems"

DOI: 10.1080/19768354.2021.1884599

Abstract: ABSTRACT Accurate chromosome segregation is required for cell survival and organismal development. During mitosis, the spindle assembly checkpoint acts as a safeguard to maintain the high fidelity of mitotic chromosome segregation by monitoring the attachment… read more here.

Keywords: bub1; mitosis; spindle assembly; bub1 kinase ... See more keywords
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Vitrification-induced activation of lysosomal cathepsin B perturbs spindle assembly checkpoint function in mouse oocytes.

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recommendations! Published in 2020 at "Molecular human reproduction"

DOI: 10.1093/molehr/gaaa051

Abstract: As the age of child-bearing increases and correlates with infertility, cryopreservation of female gametes is becoming common-place in ART. However, the developmental competence of vitrified oocytes has remained low. The underlying mechanisms responsible for reduced… read more here.

Keywords: spindle assembly; function; vitrified oocytes; assembly checkpoint ... See more keywords

Revisiting the role of the spindle assembly checkpoint in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae

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recommendations! Published in 2024 at "Genetics"

DOI: 10.1101/2024.04.11.589040

Abstract: Multiple pathways are known to suppress the formation of gross chromosomal rearrangements (GCRs), which can cause human diseases including cancer. In contrast, much less is known about pathways that promote their formation. The spindle assembly… read more here.

Keywords: formation gross; chromosomal rearrangements; assembly checkpoint; spindle assembly ... See more keywords

The HIPK2/CDC14B-MeCP2 axis enhances the spindle assembly checkpoint block by promoting cyclin B translation

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recommendations! Published in 2023 at "Science Advances"

DOI: 10.1126/sciadv.add6982

Abstract: Mitotic perturbations activate the spindle assembly checkpoint (SAC) that keeps cells in prometaphase with high CDK1 activity. Prolonged mitotic arrest is eventually bypassed by gradual cyclin B decline followed by slippage of cells into G1… read more here.

Keywords: mecp2; spindle assembly; assembly checkpoint; hipk2 cdc14b ... See more keywords

High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers

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recommendations! Published in 2019 at "Molecular Cancer Therapeutics"

DOI: 10.1158/1535-7163.mct-18-1203

Abstract: BOS172722 (CCT289346) is a highly potent, selective, and orally bioavailable inhibitor of spindle assembly checkpoint kinase MPS1. BOS172722 treatment alone induces significant sensitization to death, particularly in highly proliferative triple-negative breast cancer (TNBC) cell lines… read more here.

Keywords: bos172722; spindle assembly; assembly checkpoint; inhibitor ... See more keywords