Rapid and Highly Productive Assembly of a Disulfide Bond in Solid-Phase Peptide Macrocyclization.
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DOI: 10.1021/acs.orglett.3c00078
Abstract: Here we report a highly efficient disulfide-driven peptide macrocyclization in 15 min on a solid support using persulfate as a crucial additive in iodine-mediated oxidative cyclization. The method eliminates the side products of classical iodine-mediated… read more here.
Keywords: highly productive; productive assembly; peptide macrocyclization; assembly disulfide ... See more keywords