Linear assembly of a human centromere on the Y chromosome
Sign Up to like & getrecommendations! Published in 2018 at "Nature Biotechnology"
DOI: 10.1038/nbt.4109
Abstract: The human genome reference sequence remains incomplete owing to the challenge of assembling long tracts of near-identical tandem repeats in centromeres. We implemented a nanopore sequencing strategy to generate high-quality reads that span hundreds of… read more here.
Keywords: human centromere; linear assembly; centromere chromosome; assembly human ... See more keywords
Selective single molecule sequencing and assembly of a human Y chromosome of African origin
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-07885-5
Abstract: Mammalian Y chromosomes are often neglected from genomic analysis. Due to their inherent assembly difficulties, high repeat content, and large ampliconic regions, only a handful of species have their Y chromosome properly characterized. To date,… read more here.
Keywords: african origin; assembly human; chromosome african; human chromosome ... See more keywords