Macrocyclic Peptides Derived from Familial Alzheimer's Disease Mutants Show Charge-Dependent Oligomeric Assembly and Toxicity.
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DOI: 10.1021/acschemneuro.1c00833
Abstract: This work probes the role of charge in the oligomeric assembly, toxicity, and membrane destabilization of a series of peptides derived from Aβ and the E22Q and E22K familial mutants. In the mutant Aβ peptides,… read more here.
Keywords: assembly toxicity; peptides derived; charge; oligomeric assembly ... See more keywords