Novel explanted human liver model to assess hepatic extraction, biliary excretion and transporter function.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2905
Abstract: Realistic models predicting hepatobiliary processes in health and disease are lacking. We therefore aimed to develop a physiologically relevant human liver model consisting of normothermic machine perfusion (NMP) of explanted diseased human livers that can… read more here.
Keywords: biliary excretion; assess hepatic; model; drug ... See more keywords
A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2016.12.017
Abstract: Acetyl-coenzyme A (acetyl-CoA) is a critical metabolic signaling molecule that regulates gluconeogenesis, pyruvate oxidation, protein acetylation, and steroid and fatty acid biosynthesis; however, measurements of this metabolite using standard biochemical approaches are technically demanding, and… read more here.
Keywords: acetyl; vivo; assess hepatic; hepatic acetyl ... See more keywords