Safety Assessment of Acyl Glucuronides—A Simplified Paradigm
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DOI: 10.1124/dmd.118.080515
Abstract: While simple O- (ether-linked) and N-glucuronide drug conjugates generally are unreactive and considered benign from a safety perspective, the acyl glucuronides that derive from metabolism of carboxylic acid–containing xenobiotics can exhibit a degree of chemical… read more here.
Keywords: safety assessment; acyl glucuronides; safety; acyl ... See more keywords