In Vitro Assessment of the Hepatotoxicity Potential of Therapeutic Oligonucleotides.
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DOI: 10.1007/978-1-4939-9670-4_15
Abstract: The mechanisms of antisense oligonucleotide-induced liver toxicity are still poorly understood. Assessment of the hepatic safety profile is currently mostly investigated directly in rodent studies. A predictive preclinical in vitro model that is capturing liver… read more here.
Keywords: hepatotoxicity potential; vitro assessment; assessment hepatotoxicity; biology ... See more keywords