Comparing adaptive interventions under a general sequential multiple assignment randomized trial design via multiple comparisons with the best
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Statistical Planning and Inference"
DOI: 10.1016/j.jspi.2020.06.008
Abstract: Abstract This paper considers screening of adaptive interventions or adaptive treatment strategies embedded in a sequential multiple assignment randomized trial (SMART). As a SMART typically consists of numerous adaptive interventions, inferential procedures based on pairwise… read more here.
Keywords: trial; multiple assignment; adaptive interventions; randomized trial ... See more keywords
Interim monitoring in sequential multiple assignment randomized trials.
Sign Up to like & getrecommendations! Published in 2021 at "Biometrics"
DOI: 10.1111/biom.13562
Abstract: A sequential multiple assignment randomized trial (SMART) facilitates the comparison of multiple adaptive treatment strategies (ATSs) simultaneously. Previous studies have established a framework to test the homogeneity of multiple ATSs by a global Wald test… read more here.
Keywords: multiple assignment; monitoring sequential; interim monitoring; sequential multiple ... See more keywords
Efficient and robust approaches for analysis of sequential multiple assignment randomized trials: Illustration using the ADAPT-R trial.
Sign Up to like & getrecommendations! Published in 2022 at "Biometrics"
DOI: 10.1111/biom.13808
Abstract: Personalized intervention strategies, in particular those that modify treatment based on a participant's own response, are a core component of precision medicine approaches. Sequential multiple assignment randomized trials (SMARTs) are growing in popularity and are… read more here.
Keywords: sequential multiple; adapt trial; assignment randomized; multiple assignment ... See more keywords
Interim monitoring of sequential multiple assignment randomized trials using partial information.
Sign Up to like & getrecommendations! Published in 2022 at "Biometrics"
DOI: 10.1111/biom.13854
Abstract: The sequential multiple assignment randomized trial (SMART) is the gold standard trial design to generate data for the evaluation of multi-stage treatment regimes. As with conventional (single-stage) randomized clinical trials, interim monitoring allows early stopping;… read more here.
Keywords: sequential multiple; interim monitoring; assignment randomized; using partial ... See more keywords
Sample size considerations for comparing dynamic treatment regimens in a sequential multiple-assignment randomized trial with a continuous longitudinal outcome
Sign Up to like & getrecommendations! Published in 2019 at "Statistical Methods in Medical Research"
DOI: 10.1177/0962280219877520
Abstract: Clinicians and researchers alike are increasingly interested in how best to personalize interventions. A dynamic treatment regimen is a sequence of prespecified decision rules which can be used to guide the delivery of a sequence… read more here.
Keywords: multiple assignment; trial; randomized trial; sequential multiple ... See more keywords