TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.112192
Abstract: Changes in the cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) signaling are implicated in older people with dementia. Drugs that modulate the cAMP/cGMP levels in the brain might therefore provide new therapeutic options… read more here.
Keywords: associated aging; phosphodiesterase; cognitive impairment; tak 915 ... See more keywords
Characterization of odor markers associated with aging in old ICR mice
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-03978-6
Abstract: To identify and characterize the novel odor markers associated with aging in mice, alterations in the concentration of odorants in the urine, expression of metabolic enzymes, the histopathological structure of the sweat glands, and the… read more here.
Keywords: icr mice; associated aging; markers associated; old icr ... See more keywords
Pharmacological inhibition of USP14 delays proteostasis-associated aging in a proteasome-dependent but foxo-independent manner
Sign Up to like & getrecommendations! Published in 2024 at "Autophagy"
DOI: 10.1080/15548627.2024.2389607
Abstract: ABSTRACT Aging is often accompanied by a decline in proteostasis, manifested as an increased propensity for misfolded protein aggregates, which are prevented by protein quality control systems, such as the ubiquitin-proteasome system (UPS) and macroautophagy/autophagy.… read more here.
Keywords: pharmacological inhibition; associated aging; proteostasis associated; inhibition usp14 ... See more keywords
Integrative multiomics analysis reveals host-microbe-metabolite interplays associated with the aging process in Singaporeans
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2070392
Abstract: ABSTRACT The age-associated alterations in microbiomes vary across populations due to the influence of genetics and lifestyles. To the best of our knowledge, the microbial changes associated with aging have not yet been investigated in… read more here.
Keywords: associated aging; host microbe; age; gut oral ... See more keywords
Editors' note: The efficacy of nonpharmacologic intervention for orthostatic hypotension associated with aging
Sign Up to like & getrecommendations! Published in 2019 at "Neurology"
DOI: 10.1212/wnl.0000000000007225
Abstract: In “The efficacy of nonpharmacologic intervention for orthostatic hypotension associated with aging,” Drs. Newton and Frith reported that when 56% of participants over age 60 consumed 480 mL of tap water 20 minutes before lying… read more here.
Keywords: orthostatic hypotension; nonpharmacologic intervention; associated aging; efficacy nonpharmacologic ... See more keywords
How Does Chronobiology Contribute to the Development of Diseases in Later Life
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Interventions in Aging"
DOI: 10.2147/cia.s380436
Abstract: Abstract An increasingly older population is one of the major social and medical challenges we currently face. Between 2010 and 2050, it is estimated that the proportion of adults over 65 years of age will… read more here.
Keywords: chronobiology; associated aging; circadian rhythms; age ... See more keywords
Transcriptomic Characteristics Associated With Aging in the Thyroid Gland
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.859702
Abstract: The aging thyroid is associated with a plethora of morphological and functional changes. Limited studies have addressed the gene expression signature in the aging thyroid, except for sporadic reports using data from postmortem samples in… read more here.
Keywords: thyroid; transcriptomic characteristics; associated aging; thyroid gland ... See more keywords