TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.112192
Abstract: Changes in the cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) signaling are implicated in older people with dementia. Drugs that modulate the cAMP/cGMP levels in the brain might therefore provide new therapeutic options… read more here.
Keywords: associated aging; phosphodiesterase; cognitive impairment; tak 915 ... See more keywords
Integrative multiomics analysis reveals host-microbe-metabolite interplays associated with the aging process in Singaporeans
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2070392
Abstract: ABSTRACT The age-associated alterations in microbiomes vary across populations due to the influence of genetics and lifestyles. To the best of our knowledge, the microbial changes associated with aging have not yet been investigated in… read more here.
Keywords: associated aging; host microbe; age; gut oral ... See more keywords
Editors' note: The efficacy of nonpharmacologic intervention for orthostatic hypotension associated with aging
Sign Up to like & getrecommendations! Published in 2019 at "Neurology"
DOI: 10.1212/wnl.0000000000007225
Abstract: In “The efficacy of nonpharmacologic intervention for orthostatic hypotension associated with aging,” Drs. Newton and Frith reported that when 56% of participants over age 60 consumed 480 mL of tap water 20 minutes before lying… read more here.
Keywords: orthostatic hypotension; nonpharmacologic intervention; associated aging; efficacy nonpharmacologic ... See more keywords
How Does Chronobiology Contribute to the Development of Diseases in Later Life
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DOI: 10.2147/cia.s380436
Abstract: Abstract An increasingly older population is one of the major social and medical challenges we currently face. Between 2010 and 2050, it is estimated that the proportion of adults over 65 years of age will… read more here.
Keywords: chronobiology; associated aging; circadian rhythms; age ... See more keywords
Transcriptomic Characteristics Associated With Aging in the Thyroid Gland
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.859702
Abstract: The aging thyroid is associated with a plethora of morphological and functional changes. Limited studies have addressed the gene expression signature in the aging thyroid, except for sporadic reports using data from postmortem samples in… read more here.
Keywords: thyroid; transcriptomic characteristics; associated aging; thyroid gland ... See more keywords