Human Proteome Microarray identifies autoantibodies to tumor‐associated antigens as serological biomarkers for the diagnosis of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13371
Abstract: The identification of the high‐efficiency and non‐invasive biomarkers for hepatocellular carcinoma (HCC) detection is urgently needed. This study aims to screen out potential autoantibodies to tumor‐associated antigens (TAAbs) and to assess their diagnostic value for… read more here.
Keywords: hepatocellular carcinoma; proteome microarray; associated antigens; autoantibodies tumor ... See more keywords
Prognostic value of cross‐lineage expression of the myeloid‐associated antigens CD13 and CD33 in adult B‐lymphoblastic leukemia: A large real‐world study of 1005 patients
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5739
Abstract: Cross‐lineage expression of the myeloid‐associated antigens CD13/CD33 is common in adult B‐lymphoblastic leukemia (B‐ALL) patients, yet its prognostic value is still controversial. read more here.
Keywords: expression myeloid; lineage expression; associated antigens; antigens cd13 ... See more keywords
Targeting Tumor‐Associated Antigens in Hepatocellular Carcinoma for Immunotherapy: Past Pitfalls and Future Strategies
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DOI: 10.1002/hep.31502
Abstract: There are few treatment options for advanced-stage hepatocellular carcinoma (HCC). Targeting tumor-associated antigens (TAAs) for HCC immunotherapy has been tested clinically for many years with limited success. Recent advances in applying mutated tumor-specific neoantigens as… read more here.
Keywords: hepatocellular carcinoma; immunotherapy; targeting tumor; tumor associated ... See more keywords
Myosin II Synergizes with F-Actin to Promote DNGR-1-Dependent Cross-Presentation of Dead Cell-Associated Antigens
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DOI: 10.1016/j.celrep.2018.06.038
Abstract: Summary Conventional type 1 DCs (cDC1s) excel at cross-presentation of dead cell-associated antigens partly because they express DNGR-1, a receptor that recognizes exposed actin filaments on dead cells. In vitro polymerized F-actin can be used… read more here.
Keywords: dngr; cell associated; associated antigens; cross presentation ... See more keywords
Expression in algae of a chimeric protein carrying several epitopes from tumor associated antigens.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.12.250
Abstract: Immunotherapies for cancer treatment constitute promising avenues to fight this global health issue. Algae can be used as both biofactories and delivery vehicles of vaccines; having low cost, fast growth, enhanced safety, and adjuvant effects… read more here.
Keywords: protein; tumor associated; bcb protein; expression algae ... See more keywords
Antibodies specific for disease-associated antigens (DAA) expressed in non-malignant diseases reveal potential new tumor-associated antigens (TAA) for immunotherapy or immunoprevention.
Sign Up to like & getrecommendations! Published in 2020 at "Seminars in immunology"
DOI: 10.1016/j.smim.2020.101394
Abstract: Immune responses to a large number of mutated and non-mutated tumor antigens have been studied in an attempt to unravel the highly complex immune response to cancer. Better understanding of both the effectors and the… read more here.
Keywords: tumor associated; antigens taa; cancer; associated antigens ... See more keywords
Tumor-associated antigens in systemic lupus erythematosus: association with clinical manifestations and serological indicators.
Sign Up to like & getrecommendations! Published in 2023 at "Rheumatology"
DOI: 10.1093/rheumatology/kead224
Abstract: OBJECTIVES To explore the relationship of tumor-associated antigens (TAAs) with the clinical manifestations and serological markers of systemic lupus erythematosus (SLE). METHODS This was a retrospective study. Clinical data of SLE patients were extracted from… read more here.
Keywords: sle; positivity; clinical manifestations; associated antigens ... See more keywords
Immune checkpoint blockade lowers the threshold of naïve T-cell priming to drug-associated antigens in a dose-dependent fashion
Sign Up to like & getrecommendations! Published in 2024 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfae118
Abstract: Abstract A growing body of clinical and experimental evidence indicates that immune checkpoint blockade enhances patient susceptibility to hypersensitivity reactions to co-administered medications. In this study, we utilized an in vitro T-cell priming assay to… read more here.
Keywords: immune checkpoint; checkpoint blockade; cell; associated antigens ... See more keywords
Low-Dose Exposure to Ganglioside-Mimicking Bacteria Tolerizes Human Macrophages to Guillain-Barré Syndrome-Associated Antigens
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DOI: 10.1128/mbio.03852-21
Abstract: In this study, we demonstrated that it is possible to tolerize immune cells to potentially dampen the autoreactive proinflammatory immune response against Guillain-Barré syndrome (GBS)-associated antigens. The innate immune response functions to arm the host… read more here.
Keywords: barr syndrome; guillain barr; associated antigens; mimicking bacteria ... See more keywords
Abstract 4422: Evaluation of immune response to tumor associated antigens in patients with high grade serous ovarian cancer vaccinated intra-dermally with DCP-001, an allogeneic, cancer cell-based vaccine
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4422
Abstract: Treatment of high grade serous ovarian cancer (HGSOC) after debulking and chemotherapy remains challenging. This phase 1 trial (NCT04739527) evaluates the use of a cell-based relapse vaccine, DCP-001, to prevent disease recurrence after primary treatment.… read more here.
Keywords: cell; dcp 001; associated antigens; vaccine ... See more keywords
Abstract B124: Molecular mimicry of SARS-COV-2 antigens with tumor associated antigens
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Immunology Research"
DOI: 10.1158/2326-6074.io2025-b124
Abstract: The entire SARS-CoV-2 proteome was scanned to predict potential T cell antigens linked to HLA-A*02:01 and homology to TAAs (tumor-associated antigens) was searched by BLAST. Viral epitopes with high affinity ( read more here.
Keywords: sars cov; molecular mimicry; immunology; tumor associated ... See more keywords