Activated prothrombin complex concentrates for direct oral anticoagulant-associated bleeding or urgent surgery: Hemostatic and thrombotic outcomes.
Sign Up to like & getrecommendations! Published in 2020 at "Thrombosis research"
DOI: 10.1016/j.thromres.2020.06.044
Abstract: INTRODUCTION Studies evaluating the use of activated prothrombin complex concentrates (aPCCs) for DOAC-associated bleeding are sparse. MATERIALS AND METHODS We conducted a retrospective study of patients receiving aPCC for DOAC-associated bleeding or for pre-operative optimization… read more here.
Keywords: urgent surgery; apcc; activated prothrombin; prothrombin complex ... See more keywords
Engineering and evaluation of FXa bypassing agents that restore hemostasis following Apixaban associated bleeding
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-48278-1
Abstract: Direct oral anticoagulants (DOACs) targeting activated factor Xa (FXa) are used to prevent or treat thromboembolic disorders. DOACs reversibly bind to FXa and inhibit its enzymatic activity. However, DOAC treatment carries the risk of anticoagulant-associated… read more here.
Keywords: engineering evaluation; associated bleeding; fxa; evaluation fxa ... See more keywords
Use of Direct Oral Anticoagulant and Associated Bleeding and Thrombotic Complication after Lower Extremity Bypass.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American College of Surgeons"
DOI: 10.1097/xcs.0000000000000327
Abstract: BACKGROUND Therapeutic anticoagulation with either a vitamin K antagonist (VKA) or direct anticoagulant (DOAC) is often newly prescribed to patients undergoing lower extremity bypass (LEB) to aid in graft patency when risk factors for thrombosis… read more here.
Keywords: lower extremity; vka; associated bleeding; extremity bypass ... See more keywords
A history of variceal bleeding is associated with further bleeding under atezolizumab–bevacizumab in patients with HCC
Sign Up to like & getrecommendations! Published in 2022 at "Liver International"
DOI: 10.1111/liv.15458
Abstract: Atezolizumab–bevacizumab is the new standard for advanced hepatocellular carcinoma (HCC) but its impact on portal hypertension (PHT) is unknown. We aimed to identify predictive factors of acute variceal bleeding (AVB) and to monitor PHT parameters… read more here.
Keywords: associated bleeding; variceal bleeding; atezolizumab bevacizumab; bleeding associated ... See more keywords
Epidemiology of cancer-associated bleeding in a nationwide electronic health record database
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-703
Abstract: Background People with cancer frequently experience hemostatic imbalances that result in excessive clotting or bleeding. While the risk of thrombosis is well-studied, the lack of epidemiological data on cancer-associated bleeding limits thromboprophylaxis implementation. We examined… read more here.
Keywords: epidemiology; cancer; cohort; associated bleeding ... See more keywords
Modelling the effects of 4-factor prothrombin complex concentrate for the management of factor Xa-associated bleeding
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1371/journal.pone.0310883
Abstract: The management of factor Xa (FXa) inhibitor-associated bleeding remains a clinical challenge. Massive bleeding is often associated with complex coagulopathy and, thus, the sole reversal of FXa inhibitors might not be sufficient to restore hemostasis,… read more here.
Keywords: factor prothrombin; management factor; associated bleeding; prothrombin complex ... See more keywords
In Search of the Appropriate Anticoagulant-Associated Bleeding Risk Assessment Model for Cancer-Associated Thrombosis Patients
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14081937
Abstract: Simple Summary Patients with venous thromboembolism events in the context of cancer should receive anticoagulants as long as the cancer is active. Therefore, a tailor-made anticoagulation strategy should rely on an individualized assessment of the… read more here.
Keywords: associated bleeding; assessment; cancer; risk ... See more keywords
Sirolimus and gastrointestinal angiodysplasia: Can an established agent change the way gastrointestinal bleeding is managed?
Sign Up to like & getrecommendations! Published in 2025 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v31.i41.113736
Abstract: Gastrointestinal angiodysplasia (GIAD) is a common, acquired, vascular abnormality in the gastrointestinal tract that is commonly implicated in bleeding. Sirolimus, also known as rapamycin, is a mammalian target of rapamycin pathway inhibitor that has shown… read more here.
Keywords: associated bleeding; gastrointestinal angiodysplasia; giad associated; angiodysplasia ... See more keywords
How I manage patients with anticoagulation-associated bleeding or urgent surgery.
Sign Up to like & getrecommendations! Published in 2018 at "Swiss medical weekly"
DOI: 10.4414/smw.2018.14598
Abstract: Antithrombotic treatment puts patients at risk of major bleeding. Fast and adequate response to anticoagulant-associated bleeding may not only stop the bleeding but prevent severe complications. However, practical treatment algorithms to guide physicians in emergency… read more here.
Keywords: surgery; bleeding urgent; reversal agents; manage patients ... See more keywords