Card9‐dependent IL‐1β regulates IL‐22 production from group 3 innate lymphoid cells and promotes colitis‐associated cancer
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646765
Abstract: Inflammatory bowel diseases (IBD) are key risk factors for the development of colorectal cancer, but the mechanisms that link intestinal inflammation with carcinogenesis are insufficiently understood. Card9 is a myeloid cell‐specific signaling protein that regulates… read more here.
Keywords: card9; production group; colitis associated; cancer ... See more keywords
Experiencing financial toxicity associated with cancer in publicly funded healthcare systems: a systematic review of qualitative studies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer Survivorship"
DOI: 10.1007/s11764-021-01025-7
Abstract: Understanding how patients and families experience, respond to, and cope with the financial burden associated with cancer could assist in identifying future research priorities and developing relevant interventions to assist patients and families facing financial… read more here.
Keywords: funded healthcare; healthcare systems; publicly funded; cancer ... See more keywords
Alcohol-associated cancer and deregulation of Pol III genes.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2016.09.046
Abstract: Emerging evidence indicates that alcohol intake is associated with human cancers in different organs. However, the molecular mechanism of alcohol-associated human cancers remains to be elucidated. Here, this paper aimed to clarify a novel mechanism… read more here.
Keywords: pol iii; associated cancer; cancer deregulation; alcohol associated ... See more keywords
Low vitamin D at ICU admission is associated with cancer, infections, acute respiratory insufficiency, and liver failure.
Sign Up to like & getrecommendations! Published in 2019 at "Nutrition"
DOI: 10.1016/j.nut.2018.10.018
Abstract: OBJECTIVES Vitamin D deficiency may be associated with comorbidities and poor prognosis. However, this association in patients in the intensive care unit (ICU) has not been fully elucidated. The aim of this study was to… read more here.
Keywords: admission; admission associated; icu admission; mechanical ventilation ... See more keywords
Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes
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DOI: 10.1080/07391102.2018.1465854
Abstract: Individuals with germline mutations in the tumor suppressor gene phosphatase and tensin homolog (PTEN), irrespective of clinical presentation, are diagnosed with PTEN hamartoma tumor syndrome (PHTS). PHTS confers a high risk of breast, thyroid, and… read more here.
Keywords: pten mutations; cancer; associated cancer; germline pten ... See more keywords
Pregnancy-Associated Cancer: A U.S. Population-Based Study.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of women's health"
DOI: 10.1089/jwh.2018.6962
Abstract: BACKGROUND The incidence of pregnancy-associated cancer (PAC) is expected to increase as more women delay childbearing until later ages. However, information on frequency and incidence of PAC is scarce in the United States. METHODS We… read more here.
Keywords: incidence; pregnancy; health; associated cancer ... See more keywords
Inflammation and Inflammatory Cytokine Contribute to the Initiation and Development of Ulcerative Colitis and Its Associated Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izz149
Abstract: Dysregulated inflammatory responses play a pivotal role in the initiation, development, and progression of tumors, as demonstrated by the association between ulcerative colitis and the increased risk of colon carcinoma. In this review, the underlying… read more here.
Keywords: initiation development; inflammatory cytokine; colitis; ulcerative colitis ... See more keywords
Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn5535
Abstract: Tumor innervation is a common phenomenon with unknown mechanism. Here, we discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de novo neurogenesis via a subset showing neuronal phenotypes and pain receptor expression associated… read more here.
Keywords: associated cancer; neuron like; single cell; macrophage ... See more keywords
Systematic identification of regulatory variants associated with cancer risk
Sign Up to like & getrecommendations! Published in 2017 at "Genome Biology"
DOI: 10.1186/s13059-017-1322-z
Abstract: BackgroundMost cancer risk-associated single nucleotide polymorphisms (SNPs) identified by genome-wide association studies (GWAS) are noncoding and it is challenging to assess their functional impacts. To systematically identify the SNPs that affect gene expression by modulating… read more here.
Keywords: risk; cancer risk; regulatory variants; cancer ... See more keywords
Clostridium butyricum partially regulates the development of colitis-associated cancer through miR-200c.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2017.63.4.10
Abstract: Colitis-associated cancer (CAC), one form of colorectal cancer (CRC),is an increasing concern worldwide. Both diagnosis and current therapy are challenging and bottlenecked. The aim of this study is to investigate novel mechanisms by which the… read more here.
Keywords: associated cancer; butyricum; mir 200c; colitis associated ... See more keywords
Abnormally glycosylated MUC1 establishes a positive feedback circuit of inflammatory cytokines, mediated by NF-κB p65 and EzH2, in colitis-associated cancer
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DOI: 10.18632/oncotarget.22168
Abstract: The abnormal hypoglycosylated form of the epithelial mucin MUC1 is over-expressed in chronic inflammation and on human adenocarcinomas, suggesting its potential role in inflammation-driven tumorigenesis. The presence of human MUC1 aggravates colonic inflammation and increases… read more here.
Keywords: positive feedback; muc1; inflammatory cytokines; expression ... See more keywords