Age‐associated B cells expanded in autoimmune mice are memory cells sharing H‐CDR3‐selected repertoires
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747127
Abstract: Age‐associated B cells (ABCs) represent a distinct cell population expressing low levels of CD21 (CD21−/low). The Ig repertoire expressed by ABCs in aged mice is diverse and exhibits signs of somatic hypermutation (SHM). A CD21−/low… read more here.
Keywords: autoimmune mice; expanded autoimmune; associated cells; age associated ... See more keywords
Pathogenic Roles of Age‐Associated B Cells in Neuromyelitis Optica Spectrum Disorder
Sign Up to like & getrecommendations! Published in 2025 at "Clinical and Experimental Neuroimmunology"
DOI: 10.1111/cen3.70012
Abstract: Age‐associated B cells (ABCs), initially identified in aged mice, are a distinct B cell subset that plays crucial roles in autoimmune diseases through the production of autoantibodies, proinflammatory cytokines, and antigen presentation. Although a definitive… read more here.
Keywords: neuromyelitis optica; spectrum disorder; optica spectrum; age associated ... See more keywords
Highlights of 2024: The rising role of age‐associated B cells in autoimmune diseases
Sign Up to like & getrecommendations! Published in 2025 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.70023
Abstract: In this Research Highlight, we explore 5 influential basic and translational articles published in 2024 that shed light on the biology of age-associated B cells (ABCs) and their emerging role in autoimmunity. read more here.
Keywords: role; biology; highlights 2024; age associated ... See more keywords
Characterization of age‐associated B cells in early drug‐naïve rheumatoid arthritis patients
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13598
Abstract: Age‐associated B cells (ABCs) are an immune cell subset linked to autoimmunity, infection and ageing, and whose pathophysiological importance was recently highlighted using single cell synovial tissue profiling. To elucidate their pathophysiological relevance, peripheral blood… read more here.
Keywords: age associated; associated cells; rheumatoid arthritis; arthritis ... See more keywords
Molecular mechanisms controlling age‐associated B cells in autoimmunity *
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Reviews"
DOI: 10.1111/imr.13068
Abstract: Age‐associated B cells (ABCs) have emerged as critical components of immune responses. Their inappropriate expansion and differentiation have increasingly been linked to the pathogenesis of autoimmune disorders, aging‐associated diseases, and infections. ABCs exhibit a distinctive… read more here.
Keywords: mechanisms controlling; age associated; associated cells; molecular mechanisms ... See more keywords
Gammaherpesvirus infection drives age-associated B cells toward pathogenicity in EAE and MS
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.ade6844
Abstract: While age-associated B cells (ABCs) are known to expand and persist following viral infection and during autoimmunity, their interactions are yet to be studied together in these contexts. Here, we directly compared CD11c+T-bet+ ABCs using… read more here.
Keywords: age associated; associated cells; infection; gammaherpesvirus infection ... See more keywords
Age-Associated B Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Annual review of immunology"
DOI: 10.1146/annurev-immunol-092419-031130
Abstract: The age-associated B cell subset has been the focus of increasing interest over the last decade. These cells have a unique cell surface phenotype and transcriptional signature, and they rely on TLR7 or TLR9 signals… read more here.
Keywords: age; associated cells; age associated; cell ... See more keywords
Developmental changes in myocardial B cells mirror changes in B cells associated with different organs
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.139377
Abstract: The naive heart harbors a population of intravascular B cells that make close contact with the cardiac microvasculature. However, the timing of their appearance and their organ specificity remain unknown. To address this knowledge gap,… read more here.
Keywords: heart; analysis; myocardial cells; developmental changes ... See more keywords
Transcriptomic profiles of Mannheimia haemolytica planktonic and biofilm associated cells
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DOI: 10.1371/journal.pone.0297692
Abstract: Mannheimia haemolytica is the principal agent contributing to bovine respiratory disease and can form biofilms with increased resistance to antibiotic treatment and host immune defenses. To investigate the molecular mechanisms underlying M. haemolytica biofilm formation,… read more here.
Keywords: haemolytica; mannheimia haemolytica; planktonic biofilm; biofilm associated ... See more keywords
Age-associated B cells in viral infection
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DOI: 10.1371/journal.ppat.1010297
Abstract: Age-associated B cells (ABCs) are a recently identified, unique B cell population that displays both protective and pathogenic characteristics, depending on the context. A major role of ABCs is to protect from viral infection. ABCs… read more here.
Keywords: viral infection; cells viral; age associated; associated cells ... See more keywords
1878-LB: Specialized Lipogenic Nerve-Associated Cells Expand in Diabetic Peripheral Neuropathy
Sign Up to like & getrecommendations! Published in 2025 at "Diabetes"
DOI: 10.2337/db25-1878-lb
Abstract: Introduction and Objective: Inflammation is a key component in the pathogenesis of diabetic peripheral neuropathy (DPN), but underlying mechanisms are poorly understood. We previously identified a nerve-associated macrophage population that responds to neuroinflammatory signaling and… read more here.
Keywords: nerve associated; nerve; diabetic peripheral; cells expand ... See more keywords