Helminth‐derived molecules inhibit colitis‐associated colon cancer development through NF‐κB and STAT3 regulation
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DOI: 10.1002/ijc.32626
Abstract: Inflammation is currently considered a hallmark of cancer and plays a decisive role in different stages of tumorigenesis, including initiation, promotion, progression, metastasis and resistance to antitumor therapies. Colorectal cancer is a disease widely associated… read more here.
Keywords: colon; associated colon; colon cancer; colitis associated ... See more keywords
Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.11.050
Abstract: SUMMARY IL-10 functions as a suppressor of colitis and colitis-associated colon cancer, but it is also a risk locus associated with ulcerative colitis. The mechanism underlying the contrasting roles of IL-10 in inflammation and colon… read more here.
Keywords: dnmt3b; colon; associated colon; colitis ... See more keywords
A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aan4116
Abstract: The commonly used antimicrobial compound triclosan increases colonic inflammation and colon cancer in mice. Triclosan triggers inflammation Antimicrobials are ubiquitous in manufactured products beyond hand soap and exist in the environment as pollutants. Triclosan exposure… read more here.
Keywords: colonic inflammation; inflammation; colon; associated colon ... See more keywords
p53 Expression as a Diagnostic Biomarker in Ulcerative Colitis-Associated Cancer
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DOI: 10.3390/ijms18061284
Abstract: Ulcerative colitis (UC) is defined as an idiopathic inflammatory disorder primarily involving the mucosa and submucosa of the colon. UC-associated colon cancers (also known as colitic cancers) develop through the inflammation–dysplasia sequence, which is a… read more here.
Keywords: colon; associated colon; expression; ulcerative colitis ... See more keywords
Dietary Phenethyl Isothiocyanate Protects Mice from Colitis Associated Colon Cancer
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DOI: 10.3390/ijms18091908
Abstract: We have previously reported alleviation of dextran sodium sulfate (DSS)-induced ulcerative colitis signs in phenethyl isothiocyanate (PEITC)-treated mice. Here we investigated chemoprotective activities of PEITC in mice with Azoxymethane-DSS induced colitis associated colon carcinogenesis. We… read more here.
Keywords: colon; phenethyl isothiocyanate; colitis; associated colon ... See more keywords