Population pharmacokinetics and CSF penetration of flucytosine in adults with HIV-associated cryptococcal meningoencephalitis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkad038
Abstract: Abstract Background There are limited data describing clinical flucytosine pharmacokinetics (PK). The variability of flucytosine partitioning into the CNS is not known. We described the interindividual variability in flucytosine PK in patients with HIV-associated cryptococcal… read more here.
Keywords: associated cryptococcal; hiv associated; flucytosine; variability ... See more keywords
Equity in clinical trials for HIV-associated cryptococcal meningitis: A systematic review of global representation and inclusion of patients and researchers
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DOI: 10.1371/journal.pntd.0009376
Abstract: Background It is essential that clinical trial participants are representative of the population under investigation. Using HIV-associated cryptococcal meningitis (CM) as a case study, we conducted a systematic review of clinical trials to determine how… read more here.
Keywords: systematic review; cryptococcal meningitis; clinical trials; hiv associated ... See more keywords
The acceptability of the AMBITION-cm treatment regimen for HIV-associated cryptococcal meningitis: Findings from a qualitative methods study of participants and researchers in Botswana and Uganda
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DOI: 10.1371/journal.pntd.0010825
Abstract: Background The AMBITION-cm trial for HIV-associated cryptococcal meningitis demonstrated that a single, high-dose of liposomal amphotericin (AmBisome) plus 14-days of oral flucytosine and fluconazole was non-inferior in terms of all-cause mortality to 7-days of amphotericin… read more here.
Keywords: cryptococcal meningitis; ambisome regimen; ambition; associated cryptococcal ... See more keywords
Noninvasive intracranial pressure monitoring for HIV-associated cryptococcal meningitis
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DOI: 10.1590/1414-431x20176392
Abstract: Mortality and adverse neurologic sequelae from HIV-associated cryptococcal meningitis (HIV-CM) remains high due to raised intracranial pressure (ICP) complications. Cerebrospinal fluid (CSF) high opening pressure occurs in more than 50% of HIV-CM patients. Repeated lumbar… read more here.
Keywords: pressure; intracranial pressure; cryptococcal meningitis; hiv associated ... See more keywords