ER-to-Lysosome Associated Degradation (ERLAD) in a Nutshell: mammalian, yeast and plant ER-phagy as induced by misfolded proteins.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14674
Abstract: Conserved catabolic pathways operate to remove aberrant polypeptides from the endoplasmic reticulum (ER), the major biosynthetic organelle of eukaryotic cells. The best known are the ER-associated degradation (ERAD) pathways that control retro-translocation of terminally misfolded… read more here.
Keywords: lysosome associated; associated degradation; mammalian yeast; misfolded proteins ... See more keywords
New insights into the role of endoplasmic reticulum‐associated degradation in Bartter Syndrome Type 1
Sign Up to like & getrecommendations! Published in 2021 at "Human Mutation"
DOI: 10.1002/humu.24217
Abstract: Mutations in Na‐K‐2Cl co‐transporter, NKCC2, lead to type I Bartter syndrome (BS1), a life‐threatening kidney disease. Yet, our knowledge of the molecular regulation of NKCC2 mutants remains poor. Here, we aimed to identify the molecular… read more here.
Keywords: endoplasmic reticulum; degradation; associated degradation; bartter syndrome ... See more keywords
Selenoprotein S is required for clearance of C99 through endoplasmic reticulum-associated degradation.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.060
Abstract: Amyloid beta precursor protein (APP) is normally cleaved by α-secretase, but can also be cleaved by β-secretase (BACE1) to produce C99 fragments in the endoplasmic reticulum (ER) membrane. C99 is subsequently cleaved to amyloid β… read more here.
Keywords: degradation; endoplasmic reticulum; reticulum associated; c99 ... See more keywords
Short TRPM2 prevents the targeting of full-length TRPM2 to the surface transmembrane by hijacking to ER associated degradation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.065
Abstract: Membrane proteins are targeted to the surface transmembrane after folding and assembling in the endoplasmic reticulum (ER). Misfolded- and unassembled-proteins are degraded by proteasomes following ubiquitination, termed ER-associated degradation (ERAD). Transient receptor potential melastatin 2… read more here.
Keywords: transmembrane; full length; trpm2; short trpm2 ... See more keywords
Human cytomegalovirus evades antibody-mediated immunity through endoplasmic reticulum-associated degradation of the FcRn receptor
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10865-y
Abstract: Human cytomegalovirus (HCMV) can persistently infect humans, but how HCMV avoids humoral immunity is not clear. The neonatal Fc receptor (FcRn) controls IgG transport from the mother to the fetus and prolongs IgG half-life. Here… read more here.
Keywords: degradation; endoplasmic reticulum; human cytomegalovirus; fcrn ... See more keywords
Optineurin is an adaptor protein for ubiquitinated substrates in Golgi membrane-associated degradation
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-64400-3
Abstract: Golgi membrane-associated degradation (GOMED) is a process that leading to the degradation of proteins that have passed through the trans-Golgi membranes upon Golgi stress. GOMED is morphologically similar to autophagy, but the substrates degraded are… read more here.
Keywords: degradation gomed; membrane associated; degradation; golgi membrane ... See more keywords
Mitochondrial protein translocation-associated degradation
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1227-y
Abstract: Mitochondrial biogenesis and functions depend on the import of precursor proteins via the ‘translocase of the outer membrane’ (TOM complex). Defects in protein import lead to an accumulation of mitochondrial precursor proteins that induces a… read more here.
Keywords: precursor proteins; associated degradation; translocation associated;
ER-to-lysosome-associated degradation acts as failsafe mechanism upon ERAD dysfunction
Sign Up to like & getrecommendations! Published in 2024 at "EMBO Reports"
DOI: 10.1038/s44319-024-00165-y
Abstract: The endoplasmic reticulum (ER) produces proteins destined to organelles of the endocytic and secretory pathways, the plasma membrane, and the extracellular space. While native proteins are transported to their intra- or extracellular site of activity,… read more here.
Keywords: associated degradation; erlad pathways; lysosome associated; erad dysfunction ... See more keywords
Review: Endoplasmic Reticulum-Associated Degradation (ERAD)-Dependent Control of (Tri)terpenoid Metabolism in Plants.
Sign Up to like & getrecommendations! Published in 2018 at "Planta medica"
DOI: 10.1055/a-0635-8369
Abstract: Plants are sessile organisms. Therefore, they developed the capacity to quickly respond to biotic and abiotic environmental stresses, for instance by producing a broad spectrum of bioactive specialized metabolites. In this defense response, the jasmonate… read more here.
Keywords: endoplasmic reticulum; metabolism; degradation erad; reticulum associated ... See more keywords
Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2212644120
Abstract: Significance Systemic iron metabolism is key for cellular and organismal function. However, the subcellular regulatory mechanisms of iron homeostasis remain poorly understood. This study highlights the pathophysiological significance of a principal cellular protein quality-control mechanism… read more here.
Keywords: iron; iron homeostasis; associated degradation; systemic iron ... See more keywords
Direct binding to sterols accelerates endoplasmic reticulum-associated degradation of HMG CoA reductase
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2318822121
Abstract: Significance Endoplasmic reticulum-associated degradation (ERAD) of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase) plays a key role in the feedback regulation of cholesterol synthesis. This ERAD is stimulated by the cholesterol synthesis intermediate 24,25-dihydrolanosterol (DHL) and the… read more here.
Keywords: binding sterols; direct binding; endoplasmic reticulum; reticulum associated ... See more keywords