ER-to-Lysosome Associated Degradation (ERLAD) in a Nutshell: mammalian, yeast and plant ER-phagy as induced by misfolded proteins.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14674
Abstract: Conserved catabolic pathways operate to remove aberrant polypeptides from the endoplasmic reticulum (ER), the major biosynthetic organelle of eukaryotic cells. The best known are the ER-associated degradation (ERAD) pathways that control retro-translocation of terminally misfolded… read more here.
Keywords: lysosome associated; associated degradation; mammalian yeast; misfolded proteins ... See more keywords
New insights into the role of endoplasmic reticulum‐associated degradation in Bartter Syndrome Type 1
Sign Up to like & getrecommendations! Published in 2021 at "Human Mutation"
DOI: 10.1002/humu.24217
Abstract: Mutations in Na‐K‐2Cl co‐transporter, NKCC2, lead to type I Bartter syndrome (BS1), a life‐threatening kidney disease. Yet, our knowledge of the molecular regulation of NKCC2 mutants remains poor. Here, we aimed to identify the molecular… read more here.
Keywords: endoplasmic reticulum; degradation; associated degradation; bartter syndrome ... See more keywords
Selenoprotein S is required for clearance of C99 through endoplasmic reticulum-associated degradation.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.060
Abstract: Amyloid beta precursor protein (APP) is normally cleaved by α-secretase, but can also be cleaved by β-secretase (BACE1) to produce C99 fragments in the endoplasmic reticulum (ER) membrane. C99 is subsequently cleaved to amyloid β… read more here.
Keywords: degradation; endoplasmic reticulum; reticulum associated; c99 ... See more keywords
Short TRPM2 prevents the targeting of full-length TRPM2 to the surface transmembrane by hijacking to ER associated degradation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.065
Abstract: Membrane proteins are targeted to the surface transmembrane after folding and assembling in the endoplasmic reticulum (ER). Misfolded- and unassembled-proteins are degraded by proteasomes following ubiquitination, termed ER-associated degradation (ERAD). Transient receptor potential melastatin 2… read more here.
Keywords: transmembrane; full length; trpm2; short trpm2 ... See more keywords
Human cytomegalovirus evades antibody-mediated immunity through endoplasmic reticulum-associated degradation of the FcRn receptor
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10865-y
Abstract: Human cytomegalovirus (HCMV) can persistently infect humans, but how HCMV avoids humoral immunity is not clear. The neonatal Fc receptor (FcRn) controls IgG transport from the mother to the fetus and prolongs IgG half-life. Here… read more here.
Keywords: degradation; endoplasmic reticulum; human cytomegalovirus; fcrn ... See more keywords
Mitochondrial protein translocation-associated degradation
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1227-y
Abstract: Mitochondrial biogenesis and functions depend on the import of precursor proteins via the ‘translocase of the outer membrane’ (TOM complex). Defects in protein import lead to an accumulation of mitochondrial precursor proteins that induces a… read more here.
Keywords: precursor proteins; associated degradation; translocation associated;
Review: Endoplasmic Reticulum-Associated Degradation (ERAD)-Dependent Control of (Tri)terpenoid Metabolism in Plants.
Sign Up to like & getrecommendations! Published in 2018 at "Planta medica"
DOI: 10.1055/a-0635-8369
Abstract: Plants are sessile organisms. Therefore, they developed the capacity to quickly respond to biotic and abiotic environmental stresses, for instance by producing a broad spectrum of bioactive specialized metabolites. In this defense response, the jasmonate… read more here.
Keywords: endoplasmic reticulum; metabolism; degradation erad; reticulum associated ... See more keywords
Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2212644120
Abstract: Significance Systemic iron metabolism is key for cellular and organismal function. However, the subcellular regulatory mechanisms of iron homeostasis remain poorly understood. This study highlights the pathophysiological significance of a principal cellular protein quality-control mechanism… read more here.
Keywords: iron; iron homeostasis; associated degradation; systemic iron ... See more keywords
Proteasomal and lysosomal clearance of faulty secretory proteins: ER-associated degradation (ERAD) and ER-to-lysosome-associated degradation (ERLAD) pathways
Sign Up to like & getrecommendations! Published in 2019 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2019.1610351
Abstract: Abstract About 40% of the eukaryotic cell’s proteins are inserted co- or post-translationally in the endoplasmic reticulum (ER), where they attain the native structure under the assistance of resident molecular chaperones and folding enzymes. Subsequently,… read more here.
Keywords: degradation; degradation erad; clearance; degradation erlad ... See more keywords
Augmented ERAD (ER-associated degradation) activity in chondrocytes is necessary for cartilage development and maintenance
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl4222
Abstract: Chondrocytes secrete massive extracellular matrix (ECM) molecules that are produced, folded, and modified in the endoplasmic reticulum (ER). Thus, the ER-associated degradation (ERAD) complex—which removes misfolded and unfolded proteins to maintain proteostasis in the ER—… read more here.
Keywords: associated degradation; maintenance; cartilage; erad ... See more keywords
Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.206847
Abstract: ABSTRACT The mammalian ubiquitin ligase Hrd1 is the central component of a complex facilitating degradation of misfolded proteins during the ubiquitin–proteasome-dependent process of ER-associated degradation (ERAD). Hrd1 associates with cofactors to execute ERAD, but their… read more here.
Keywords: degradation; degradation erad; hrd1; ubiquitin ligase ... See more keywords