Chronic sun exposure is associated with distinct histone acetylation changes in human skin
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Dermatology"
DOI: 10.1111/bjd.16129
Abstract: Photoageing is attributed to continuous sunlight or artificial ultraviolet exposure and manifests as clinical and histological changes in skin. Epigenetic changes have been found to be involved in the pathogenesis of photoageing. However, the underlying… read more here.
Keywords: distinct histone; associated distinct; chronic sun; sun exposure ... See more keywords
Nivolumab and ipilimumab are associated with distinct immune landscape changes and response-associated immunophenotypes.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.137066
Abstract: BACKGROUND The reshaping of the immune landscape by nivolumab (NIVO) and ipilimumab (IPI) and its relation to patient outcomes is not well-described. METHODS We used high-parameter flow cytometry and a novel computational platform, CytoBrute, to… read more here.
Keywords: ipi nivo; ipi; response; immune landscape ... See more keywords
PD-L1 positive esophagogastric (EG) cancer is associated with distinct bacteria.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.4568
Abstract: 4568Background: Pembrolizumab is approved for chemotherapy-refractory PD-L1 CPS >1 mEG cancer. In clinical trials, pts with MSI-H, EBV+ and PD-L1 CPS >10 EG cancers derive the greatest benefit with... read more here.
Keywords: positive esophagogastric; distinct bacteria; esophagogastric cancer; cancer ... See more keywords