Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05912-z
Abstract: Lamins (A/C and B) are major constituents of the nuclear lamina (NL). Structurally conserved lamina-associated domains (LADs) are formed by genomic regions that contact the NL. Lamins are also found in the nucleoplasm, with a… read more here.
Keywords: lamina associated; euchromatin lamin; associated domains; euchromatin ... See more keywords
Structural basis of diversity and homodimerization specificity of zinc-finger-associated domains in Drosophila
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab061
Abstract: Abstract In arthropods, zinc finger-associated domains (ZADs) are found at the N-termini of many DNA-binding proteins with tandem arrays of Cys2-His2 zinc fingers (ZAD-C2H2 proteins). ZAD-C2H2 proteins undergo fast evolutionary lineage-specific expansion and functional diversification.… read more here.
Keywords: zinc; zinc finger; associated domains; finger associated ... See more keywords
3D organization of chicken genome demonstrates evolutionary conservation of topologically associated domains and highlights unique architecture of erythrocytes’ chromatin
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky1103
Abstract: Abstract How chromosomes are folded, spatially organized and regulated in three dimensions inside the cell nucleus are among the longest standing questions in cell biology. Genome-wide chromosome conformation capture (Hi-C) technique allowed identifying and characterizing… read more here.
Keywords: organization chicken; associated domains; topologically associated; chicken genome ... See more keywords
Topokaryotyping demonstrates single cell variability and stress dependent variations in nuclear envelope associated domains
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DOI: 10.1093/nar/gky818
Abstract: Abstract Analysis of large-scale interphase genome positioning with reference to a nuclear landmark has recently been studied using sequencing-based single cell approaches. However, these approaches are dependent upon technically challenging, time consuming and costly high… read more here.
Keywords: single cell; nuclear envelope; associated domains; stress ... See more keywords
Local euchromatin enrichment in lamina-associated domains anticipates their repositioning in the adipogenic lineage
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DOI: 10.1186/s13059-022-02662-6
Abstract: Background Interactions of chromatin with the nuclear lamina via lamina-associated domains (LADs) confer structural stability to the genome. The dynamics of positioning of LADs during differentiation, and how LADs impinge on developmental gene expression, remains,… read more here.
Keywords: lineage; associated domains; differentiation; lamina ... See more keywords