AQP4 Aggravates Cognitive Impairment in Sepsis‐Associated Encephalopathy through Inhibiting Nav1.6‐Mediated Astrocyte Autophagy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205862
Abstract: The pathology of sepsis‐associated encephalopathy (SAE) is related to astrocyte‐inflammation associated with aquaporin‐4 (AQP4). The aim here is to investigate the effects of AQP4 associated with SAE and reveal its underlying mechanism causing cognitive impairment.… read more here.
Keywords: associated encephalopathy; cognitive impairment; sepsis associated; astrocyte ... See more keywords
Potentially modifiable factors contributing to sepsis-associated encephalopathy
Sign Up to like & getrecommendations! Published in 2017 at "Intensive Care Medicine"
DOI: 10.1007/s00134-017-4807-z
Abstract: PurposeIdentifying modifiable factors for sepsis-associated encephalopathy may help improve patient care and outcomes.MethodsWe conducted a retrospective analysis of a prospective multicenter database. Sepsis-associated encephalopathy (SAE) was defined by a score on the Glasgow coma scale… read more here.
Keywords: factors contributing; associated encephalopathy; sepsis associated; potentially modifiable ... See more keywords
Astroglia in Sepsis Associated Encephalopathy
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02743-2
Abstract: Cellular pathophysiology of sepsis associated encephalopathy (SAE) remains poorly characterised. Brain pathology in SAE, which is manifested by impaired perception, consciousness and cognition, results from multifactorial events, including high levels of systemic cytokines, microbial components… read more here.
Keywords: astroglia sepsis; associated encephalopathy; pathology; sepsis associated ... See more keywords
Role of microRNAs As Biomarkers in Sepsis-Associated Encephalopathy
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurobiology"
DOI: 10.1007/s12035-021-02445-3
Abstract: Sepsis-associated encephalopathy (SAE) is a neurological complication of sepsis, characterized by brain dysfunction without any direct central nervous system infection. The diagnosis of SAE is currently a challenge. In fact, problems in making a diagnosis… read more here.
Keywords: micrornas biomarkers; diagnosis; associated encephalopathy; sepsis associated ... See more keywords
Epidemiological changes of acute encephalopathy in Japan based on national surveillance for 2014–2017
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DOI: 10.1016/j.braindev.2020.04.006
Abstract: BACKGROUND We previously reported the nationwide, epidemiological data of acute encephalopathy in Japan during 2007-2010. Here we conducted the second national survey of acute encephalopathy during 2014-2017, and compared the results between the two studies… read more here.
Keywords: epidemiological changes; associated encephalopathy; acute encephalopathy; japan ... See more keywords
Cytokine release syndrome‐associated encephalopathy in patients with COVID‐19
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Neurology"
DOI: 10.1111/ene.14491
Abstract: Neurological manifestations in coronavirus disease (COVID)‐2019 may adversely affect clinical outcomes. Severe COVID‐19 and uremia are risk factors for neurological complications. However, the lack of insight into their pathogenesis, particularly with respect to the role… read more here.
Keywords: syndrome associated; cytokine release; associated encephalopathy; release syndrome ... See more keywords
Clinical manifestations of respiratory syncytial virus‐associated encephalopathy in Fukushima, Japan
Sign Up to like & getrecommendations! Published in 2019 at "Pediatrics International"
DOI: 10.1111/ped.13928
Abstract: We investigated the epidemiology and clinical course of children with respiratory syncytial virus (RSV)‐associated encephalopathy. read more here.
Keywords: respiratory syncytial; syncytial virus; associated encephalopathy; manifestations respiratory ... See more keywords
Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.abq7806
Abstract: Sepsis-associated encephalopathy (SAE) is a severe and frequent complication of sepsis causing delirium, coma, and long-term cognitive dysfunction. We identified microglia and C1q complement activation in hippocampal autopsy tissue of patients with sepsis and increased… read more here.
Keywords: sepsis; associated encephalopathy; tagged synapses; sepsis associated ... See more keywords
Iatrogenic coma: ceftriaxone-associated encephalopathy
Sign Up to like & getrecommendations! Published in 2018 at "Postgraduate Medical Journal"
DOI: 10.1136/postgradmedj-2017-134999
Abstract: A 76-year-old heavy smoker with vascular disease, mitral valve repair and creatinine 1.4 mg/dL was admitted with fever. Blood cultures grew Enterococcus faecalis and echocardiography demonstrated mitral and aortic valve vegetations. Ceftriaxone (2 g twice daily) and… read more here.
Keywords: ceftriaxone associated; iatrogenic coma; coma ceftriaxone; associated encephalopathy ... See more keywords
Exploring the Biomarkers of Sepsis-Associated Encephalopathy (SAE): Metabolomics Evidence from Gas Chromatography-Mass Spectrometry
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DOI: 10.1155/2019/2612849
Abstract: Background Sepsis-associated encephalopathy (SAE) is a transient and reversible brain dysfunction, that occurs when the source of sepsis is located outside of the central nervous system; SAE affects nearly 30% of septic patients at admission… read more here.
Keywords: gas chromatography; sae; mass; encephalopathy sae ... See more keywords
(−)-Epicatechin Reduces Neuroinflammation, Protects Mitochondria Function, and Prevents Cognitive Impairment in Sepsis-Associated Encephalopathy
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2657713
Abstract: Sepsis-associated encephalopathy is a common neurological complication of sepsis. Despite advances in pathological and diagnostic investigations, its treatment remains a major challenge. In sepsis-associated encephalopathy, neuroinflammatory overactivation and mitochondrial damage are thought to contribute to… read more here.
Keywords: sepsis; neuroinflammation; mitochondria function; associated encephalopathy ... See more keywords