Tumor-Associated Enzyme-Activatable Spherical Nucleic Acids.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c03323
Abstract: Maximizing the tissue-targeting efficiency of nanomaterials while also protecting them from rapid clearance from the bloodstream and limiting their immunogenicity remains a central problem in the field of systemic-administered nanomedicine. Herein, we introduce a generalizable… read more here.
Keywords: tumor accumulation; associated enzyme; spherical nucleic; tumor ... See more keywords
Abstract 814: A novel small molecule prodrug activated inside cancer cells by a tumor associated enzyme for targeted chemotherapeutics in kidney cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-814
Abstract: Brimstalt Therapeutics is developing a small molecule drug for treatment of cancer patients with tumors that express the tumor associated enzyme (TAE), SULT1A1. The lead compound, BST-12, is a prodrug that is activated by SULT1A1,… read more here.
Keywords: cancer; kidney; associated enzyme; tumor associated ... See more keywords