LAMC1 upregulation via TGFβ induces inflammatory cancer-associated fibroblasts in esophageal squamous cell carcinoma via NF-κB-CXCL1-STAT3.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13053
Abstract: Cancer-associated fibroblasts (CAFs) are a heterogenous cell population within the tumor microenvironment, and play an important role in tumor development. By regulating the heterogeneity of CAFs, transforming growth factor β (TGFβ) influences tumor development. Here,… read more here.
Keywords: associated fibroblasts; tgf; cancer associated; cell ... See more keywords
Cancer‐associated fibroblasts in breast cancer: Challenges and opportunities
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12291
Abstract: The tumor microenvironment is proposed to contribute substantially to the progression of cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most abundant components of the tumor microenvironment. Studies have revealed that CAFs in breast… read more here.
Keywords: fibroblasts breast; breast cancer; associated fibroblasts; cancer associated ... See more keywords
Targeting Metabolic Cross Talk between Cancer Cells and Cancer-Associated Fibroblasts.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-77736-8_12
Abstract: KEY POINTS Although tumorigenesis has classically been regarded as a genetic disease of uncontrolled cell growth, the importance of the tumor microenvironment (TME) is continuously emphasized by the accumulating evidence that cancer growth is not… read more here.
Keywords: cross talk; associated fibroblasts; talk cancer; cancer cells ... See more keywords
Effects of cytokines derived from cancer-associated fibroblasts on androgen synthetic enzymes in estrogen receptor-negative breast carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-017-4464-5
Abstract: PurposeThe tumor microenvironment plays pivotal roles in promotion of many malignancies. Cancer-associated fibroblasts (CAFs) have been well-known to promote proliferation, angiogenesis, and metastasis but mechanistic understanding of tumor–stroma interactions is not yet complete. Recently, estrogen… read more here.
Keywords: breast carcinoma; synthetic enzymes; androgen synthetic; associated fibroblasts ... See more keywords
Review of cancer-associated fibroblasts and their microenvironment in post-chemotherapy recurrence.
Sign Up to like & getrecommendations! Published in 2020 at "Human cell"
DOI: 10.1007/s13577-020-00417-8
Abstract: Cancer tissue comprises not only cancer cells, but also several types of non-cancerous cells, such as cancer-associated fibroblasts. These fibroblasts directly and/or indirectly communicate with the cancer cells and other types of stromal cells, to… read more here.
Keywords: chemotherapy; recurrence; associated fibroblasts; cancer cells ... See more keywords
PTEN in cancer associated fibroblasts.
Sign Up to like & getrecommendations! Published in 2022 at "Advances in cancer research"
DOI: 10.1016/bs.acr.2022.01.002
Abstract: Decades of research have concluded that disruptions to Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) have profound effects on cancer progression. However, as our understanding of the tumor stroma has evolved, we can… read more here.
Keywords: associated fibroblasts; cancer associated; cancer; pten cancer ... See more keywords
Force-dependent extracellular matrix remodeling by early-stage cancer cells alters diffusion and induces carcinoma-associated fibroblasts.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.119756
Abstract: It is known cancer cells secrete cytokines inducing normal fibroblasts (NFs) to become carcinoma-associated fibroblasts (CAFs). However, it is not clear how the CAF-promoting cytokines can effectively navigate the dense ECM, a diffusion barrier, in… read more here.
Keywords: diffusion; caf; associated fibroblasts; carcinoma associated ... See more keywords
PERK-eIF2α-ERK1/2 axis drives mesenchymal-endothelial transition of cancer-associated fibroblasts in pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.05.021
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is characterized by remarkable desmoplasia, usually driven by cancer-associated fibroblasts (CAFs), influencing patient prognosis. CAFs are a group of plastic cells responsible for tumor growth and metastasis. Fibroblasts have been reported… read more here.
Keywords: transition; associated fibroblasts; mesenchymal endothelial; cancer ... See more keywords
Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors.
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DOI: 10.1016/j.ccell.2017.10.005
Abstract: Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects. Here, we have identified the mechanism that limited… read more here.
Keywords: csf1r; infiltration tumors; associated fibroblasts; effect ... See more keywords
Cancer-associated fibroblasts: key determinants of tumor immunity and immunotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2020.03.004
Abstract: Immune-targeted approaches are rapidly changing the therapeutic landscape for cancer. In spite of that, most patients show resistance or acquire resistance to these therapies. Increasing work describing the tumor microenvironment (TME) has highlighted this space… read more here.
Keywords: key determinants; immunotherapy; associated fibroblasts; determinants tumor ... See more keywords
Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in the Tumor Microenvironment After Radiotherapy
Sign Up to like & getrecommendations! Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.03.004
Abstract: Article history: Received 2 March 2017 Accepted 2 March 2017 Available online 4 March 2017 that these secreted factors derived from CAFs increased reactive oxygen species (ROS) levels in irradiated cancer cells, enhancing PP2A activity… read more here.
Keywords: march 2017; associated fibroblasts; crosstalk cancer; cancer cells ... See more keywords