Mendelian analysis reveals novel pancreatic cancer-associated gut bacteria with tumor-suppressive effects.
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DOI: 10.1007/s13402-025-01098-x
Abstract: The gut microbiota has been implicated in the development and progression of pancreatic cancer (PC), yet few specific bacterial species have been reported to exert functional effect on PC. This study aimed to identify novel… read more here.
Keywords: pancreatic cancer; analysis; suppressive effects; associated gut ... See more keywords
Relationship between mucosa-associated gut microbiota and human diseases
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20201201
Abstract: The mucus layer covering the gastrointestinal (GI) tract plays a critical role in maintaining gut homeostasis. In the colon, the inner mucus layer ensures commensal microbes are kept at a safe distance from the epithelium… read more here.
Keywords: microbiota; human diseases; associated gut; relationship mucosa ... See more keywords
Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2311313121
Abstract: Significance Human life expectancy has increased markedly during the last decades thanks to advances in medicine, hygiene, and nutrition, among other factors. However, this demographic change brings an increased prevalence of age-related diseases, such as… read more here.
Keywords: trametinib ameliorates; iii; pathology; aging associated ... See more keywords
Depression-associated gut microbes, metabolites and clinical trials
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DOI: 10.3389/fmicb.2024.1292004
Abstract: Depression is one of the most prevalent mental disorders today. Over the past decade, there has been considerable attention given to the field of gut microbiota associated with depression. A substantial body of research indicates… read more here.
Keywords: gut microbiota; depression associated; gut microbes; depression ... See more keywords
Modeling the effects of prebiotic interventions on luminal and mucosa-associated gut microbiota without and with Clostridium difficile challenge in vitro
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DOI: 10.3389/fnut.2024.1403007
Abstract: Prebiotics can modulate the gut microbial community composition and function for improved (gut) health and increase resilience against infections. In vitro models of the gut facilitate the study of intervention effects on the gut microbial… read more here.
Keywords: mucosa; mucosa associated; culture; vitro ... See more keywords
HIV-associated gut dysbiosis drives oncogenesis through metabolic-immune crosstalk: mechanisms and therapeutic implications
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2025.1634388
Abstract: HIV-induced gut microbiota dysbiosis perpetuates mucosal barrier disruption and systemic inflammation despite antiretroviral therapy (ART), creating a tumor-permissive microenvironment. This review synthesizes evidence linking HIV-associated microbial alterations to oncogenesis through three convergent metabolic axes: (1)… read more here.
Keywords: gut dysbiosis; dysbiosis; hiv associated; drives oncogenesis ... See more keywords