An Open‐Label, Dose‐Escalation Study to Assess the Safety and Efficacy of IL‐22 Agonist F‐652 in Patients With Alcohol‐associated Hepatitis
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DOI: 10.1002/hep.31046
Abstract: Interleukin‐22 has beneficial effects on inflammation and impaired hepatic regeneration that characterize alcohol‐associated hepatitis (AH). F‐652 is a recombinant fusion protein of human interleukin‐22 and immunoglobulin G2 fragment crystallizable. This study aims to assess the… read more here.
Keywords: associated hepatitis; alcohol associated; safety efficacy; 652 patients ... See more keywords
IL-1 receptor antagonist plus pentoxifylline and zinc for severe alcohol-associated hepatitis.
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DOI: 10.1002/hep.32478
Abstract: BACKGROUND & AIMS Patients with severe alcohol-associated hepatitis (AH) have high mortality. Corticosteroids improve survival only for 30 days. We targeted inflammation, cellular injury and gut leakiness in a randomized clinical trial comparing combination therapy… read more here.
Keywords: survival; alcohol associated; associated hepatitis; severe alcohol ... See more keywords
Malnutrition and Alcohol-Associated Hepatitis.
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DOI: 10.1016/j.cld.2021.03.002
Abstract: Malnutrition is common in alcohol-associated hepatitis (AH); almost all patients with severe AH have some component of malnutrition. The classic phenotype of malnutrition in AH is sarcopenia, but this has become more difficult to discern… read more here.
Keywords: associated hepatitis; alcohol associated; malnutrition; alcohol ... See more keywords
Current Therapies for Alcohol-Associated Hepatitis.
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DOI: 10.1016/j.cld.2021.03.005
Abstract: Alcohol-associated hepatitis is associated with poor outcomes, especially when severe. Despite extensive study with a plethora of potential therapeutic agents, treatment options remain limited, with the current standard of therapy being corticosteroids. Granulocyte colony-stimulating factor… read more here.
Keywords: current therapies; associated hepatitis; alcohol associated; therapies alcohol ... See more keywords
5S rRNA pseudogene transcripts are associated with interferon production and inflammatory responses in alcohol-associated hepatitis
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DOI: 10.1097/hep.0000000000000024
Abstract: Background and Aims: Interferon (IFN) signaling is critical to the pathogenesis of alcohol-associated hepatitis (AH), yet the mechanisms for activation of this system are elusive. We hypothesize that host-derived 5S rRNA pseudogene (RNA5SP) transcripts regulate… read more here.
Keywords: associated hepatitis; rna5sp transcripts; production; alcohol associated ... See more keywords
Multicentered study of patient outcomes after declined for early liver transplantation in severe alcohol-associated hepatitis
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DOI: 10.1097/hep.0000000000000267
Abstract: Background: Early liver transplantation for alcohol-associated hepatitis is controversial in part because patients may recover, and obviate the need for liver transplantation. Methods: In this retrospective study among 5 ACCELERATE-AH sites, we randomly sampled patients… read more here.
Keywords: alcohol; alcohol associated; liver transplantation; associated hepatitis ... See more keywords
Immunoglobulin Y antibodies against cytolysin reduce ethanol-induced liver disease in mice.
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DOI: 10.1097/hep.0000000000000324
Abstract: BACKGROUND Patients with severe alcohol-associated hepatitis have a high morbidity and mortality. Novel therapeutic approaches are urgently needed. Aims of our study were to confirm the predictive value of cytolysin-positive Enterococcus faecalis (E. faecalis) for… read more here.
Keywords: associated hepatitis; antibodies cytolysin; ethanol induced; alcohol associated ... See more keywords
Corticosteroids in severe alcohol-associated hepatitis? Not so fast: A systematic review of randomized controlled trials.
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DOI: 10.1097/hep.0000000000001237
Abstract: BACKGROUND Severe alcohol-associated hepatitis (AH) is rising in incidence with a high mortality burden. While corticosteroids are recommended for eligible patients with severe AH, no guidance exists for the timing of steroid initiation, tapering regimens,… read more here.
Keywords: adverse events; associated hepatitis; alcohol associated; corticosteroids severe ... See more keywords
Clinical outcomes and associated bacterial and fungal microbiota changes after high dose probiotic therapy for severe alcohol-associated hepatitis: An observational study
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DOI: 10.1097/md.0000000000040429
Abstract: Alcohol-associated hepatitis (AH) is a critical condition with high mortality rates and is worsened by infections. Organ failure is strongly associated with intestinal dysbiosis. Emerging research suggests that gut microbiota modulation with probiotics can improve… read more here.
Keywords: associated hepatitis; alcohol associated; bacterial fungal; fungal ... See more keywords
Liver transplantation for alcohol-associated hepatitis
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DOI: 10.1097/mot.0000000000001044
Abstract: Purpose of review Early liver transplantation is emerging as a treatment option for severe alcohol-associated hepatitis refractory to pharmacotherapies. This review outlines the current status of transplantation for alcohol-associated hepatitis and the treatment of alcohol… read more here.
Keywords: associated hepatitis; alcohol associated; transplantation; alcohol ... See more keywords
Current insights into pathogenesis and anti‐inflammatory treatment strategies for severe alcohol‐associated hepatitis: focus on neutrophil‐targeted therapies
Sign Up to like & getrecommendations! Published in 2025 at "Hepatology Research"
DOI: 10.1111/hepr.14206
Abstract: Alcohol‐associated hepatitis (AH) is the leading cause of liver‐related mortality, with severe alcohol‐associated hepatitis (SAH) showing a short‐term mortality rate of 20%–50% even in developed countries. Corticosteroids are the only evidence‐based pharmacologic treatment, but their… read more here.
Keywords: treatment; associated hepatitis; alcohol associated; sah ... See more keywords