Social behavioral correlates of Kaposi sarcoma–associated herpesvirus infection among Han and Uygur populations in Xinjiang, China
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DOI: 10.1002/jmv.25332
Abstract: Kaposi sarcoma–associated herpesvirus (KSHV) is endemic in Xinjiang, China and its prevalence varies considerably across ethnic groups. The current study explored the prevalence and correlates of KSHV infection among Han and Uygur populations in Xinjiang. read more here.
Keywords: kaposi sarcoma; infection among; among han; xinjiang china ... See more keywords
Human leukocyte antigen polymorphisms and Kaposi's sarcoma‐associated herpesvirus infection outcomes: A call for deeper exploration
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DOI: 10.1002/jmv.25342
Abstract: Host genetic background may influence the immunity to resist viral infection. As the most polymorphic loci in the entire human genome, the human leukocyte antigen (HLA) system plays an important role in innate and adaptive… read more here.
Keywords: kaposi sarcoma; infection; human leukocyte; associated herpesvirus ... See more keywords
Runaway Kaposi Sarcoma-associated herpesvirus replication correlates with systemic IL-10 levels.
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DOI: 10.1016/j.virol.2019.10.002
Abstract: KSHV-associated inflammatory cytokine syndrome (KICS) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV). KICS is associated with high-level, systemic replication of KSHV. This study characterized the clinical and virologic features of a KICS patient over time.… read more here.
Keywords: sarcoma; kaposi sarcoma; kshv; associated herpesvirus ... See more keywords
Homology-directed repair in mouse cells increased by CasRx-mediated knockdown or co-expressing Kaposi’s sarcoma-associated herpesvirus ORF52
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DOI: 10.1042/bsr20191914
Abstract: Abstract Precise genome editing with directed base insertion or targeted point mutations can be achieved by CRISPR/Cas9-mediated homology-directed repair (HDR) and is of great significance in clinical disease therapy. However, HDR efficiency, compared with non-homologous… read more here.
Keywords: sarcoma associated; kaposi sarcoma; associated herpesvirus; directed repair ... See more keywords
Kaposi's sarcoma–associated herpesvirus replication and transcription activator protein activates CD274/PD‐L1 gene promoter
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DOI: 10.1111/cas.15673
Abstract: Kaposi's sarcoma–associated herpesvirus (KSHV) is responsible for the pathogenesis of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman disease. The expression of immunosuppressive genes, such as IL‐10 and CD274/PD‐L1 is observed during KSHV‐associated pathogenesis, and… read more here.
Keywords: promoter; kaposi sarcoma; associated herpesvirus; cd274 gene ... See more keywords
Conserved CxnC Motifs in Kaposi’s Sarcoma-Associated Herpesvirus ORF66 Are Required for Viral Late Gene Expression and Are Essential for Its Interaction with ORF34
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DOI: 10.1128/jvi.01299-19
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV; human herpesvirus 8) is an oncogenic gammaherpesvirus that is the causative agent of multiple human cancers. The release of infectious virions requires the production of capsid proteins and other late genes,… read more here.
Keywords: sarcoma associated; late gene; kaposi sarcoma; associated herpesvirus ... See more keywords
Upregulation of ATF4-LAMP3 Axis by ORF45 Facilitates Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus
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DOI: 10.1128/jvi.01456-22
Abstract: The lytic replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) reprograms cellular transcription and translation to generate viral proteins and virion particles. Here, we show that the mediator of ER stress ATF4 and the expression of the… read more here.
Keywords: lytic replication; replication; lamp3; kaposi sarcoma ... See more keywords
Kaposi's Sarcoma-Associated Herpesvirus MicroRNA Mutants Modulate Cancer Hallmark Phenotypic Differences in Human Endothelial Cells
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DOI: 10.1128/jvi.02022-20
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) causes Kaposi’s sarcoma (KS). The contribution of KSHV microRNAs (miRNAs) to oncogenesis is not fully understood. ABSTRACT Kaposi’s sarcoma (KS) results from the transformation of Kaposi's sarcoma-associated herpesvirus (KSHV)-infected endothelial cells.… read more here.
Keywords: sarcoma associated; kaposi sarcoma; associated herpesvirus; kshv ... See more keywords
Kaposi’s sarcoma-associated herpesvirus latency-associated nuclear antigen dysregulates expression of MCL-1 by targeting FBW7
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DOI: 10.1371/journal.ppat.1009179
Abstract: Primary effusion lymphoma (PEL) is an aggressive B cell lymphoma that is etiologically linked to Kaposi’s sarcoma-associated herpesvirus (KSHV). Despite standard multi-chemotherapy treatment, PEL continues to cause high mortality. Thus, new strategies to control PEL… read more here.
Keywords: associated nuclear; kaposi sarcoma; latency associated; nuclear antigen ... See more keywords
Kaposi’s sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies
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DOI: 10.1371/journal.ppat.1011080
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) causes the inflammatory and angiogenic endothelial cell neoplasm, Kaposi’s sarcoma (KS). We previously demonstrated that expression of the KSHV protein, Kaposin B (KapB), promoted inflammation via the disassembly of cytoplasmic ribonucleoprotein… read more here.
Keywords: kshv; kaposi sarcoma; processing bodies; associated herpesvirus ... See more keywords
Modulation of Angiogenic Processes by the Human Gammaherpesviruses, Epstein–Barr Virus and Kaposi’s Sarcoma-Associated Herpesvirus
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DOI: 10.3389/fmicb.2019.01544
Abstract: Angiogenesis is the biological process by which new blood vessels are formed from pre-existing vessels. It is considered one of the classic hallmarks of cancer, as pathological angiogenesis provides oxygen and essential nutrients to growing… read more here.
Keywords: epstein barr; kaposi sarcoma; barr virus; associated herpesvirus ... See more keywords