Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B
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DOI: 10.1002/advs.202502231
Abstract: Kaposi's sarcoma‐associated herpesvirus (KSHV), a member of the human γ‐herpesviruses family, exhibits extensive cellular tropism and is associated with Kaposi's sarcoma and various B‐cell malignancies. Despite its clinical significance, no effective prophylactic vaccines or specific… read more here.
Keywords: structure antigenicity; structure; associated herpesvirus; kaposi sarcoma ... See more keywords
Social behavioral correlates of Kaposi sarcoma–associated herpesvirus infection among Han and Uygur populations in Xinjiang, China
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DOI: 10.1002/jmv.25332
Abstract: Kaposi sarcoma–associated herpesvirus (KSHV) is endemic in Xinjiang, China and its prevalence varies considerably across ethnic groups. The current study explored the prevalence and correlates of KSHV infection among Han and Uygur populations in Xinjiang. read more here.
Keywords: kaposi sarcoma; infection among; among han; xinjiang china ... See more keywords
Human leukocyte antigen polymorphisms and Kaposi's sarcoma‐associated herpesvirus infection outcomes: A call for deeper exploration
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DOI: 10.1002/jmv.25342
Abstract: Host genetic background may influence the immunity to resist viral infection. As the most polymorphic loci in the entire human genome, the human leukocyte antigen (HLA) system plays an important role in innate and adaptive… read more here.
Keywords: kaposi sarcoma; infection; human leukocyte; associated herpesvirus ... See more keywords
Runaway Kaposi Sarcoma-associated herpesvirus replication correlates with systemic IL-10 levels.
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DOI: 10.1016/j.virol.2019.10.002
Abstract: KSHV-associated inflammatory cytokine syndrome (KICS) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV). KICS is associated with high-level, systemic replication of KSHV. This study characterized the clinical and virologic features of a KICS patient over time.… read more here.
Keywords: sarcoma; kaposi sarcoma; kshv; associated herpesvirus ... See more keywords
Homology-directed repair in mouse cells increased by CasRx-mediated knockdown or co-expressing Kaposi’s sarcoma-associated herpesvirus ORF52
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DOI: 10.1042/bsr20191914
Abstract: Abstract Precise genome editing with directed base insertion or targeted point mutations can be achieved by CRISPR/Cas9-mediated homology-directed repair (HDR) and is of great significance in clinical disease therapy. However, HDR efficiency, compared with non-homologous… read more here.
Keywords: sarcoma associated; kaposi sarcoma; associated herpesvirus; directed repair ... See more keywords
Infant feeding and treatment practices could lead to enhanced transmission of Kaposi’s sarcoma-associated herpesvirus (KSHV) and other orally shed infections via saliva, in rural south-western Uganda
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DOI: 10.1080/17441692.2024.2418594
Abstract: ABSTRACT This qualitative sub-study investigated household practices affecting orally shed infections using Kaposi’s sarcoma-associated herpesvirus (KSHV) as a focus. Participants enrolled from 50 households in rural south-western Uganda were followed monthly up to three times.… read more here.
Keywords: kshv; associated herpesvirus; kaposi sarcoma; sarcoma associated ... See more keywords
Population Genetic Structure and Human Adaptation of Kaposi Sarcoma–Associated Herpesvirus
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DOI: 10.1093/ofid/ofaf111
Abstract: Abstract Background Kaposi sarcoma–associated herpesvirus (KSHV), the etiologic agent of Kaposi sarcoma, is human-specific and is thought to have emerged from primate-infecting gammaherpesviruses. KSHV seroprevalence shows geographic variation, being highest in sub-Saharan Africa, intermediate in… read more here.
Keywords: adaptation; structure; associated herpesvirus; kaposi sarcoma ... See more keywords
Kaposi's sarcoma–associated herpesvirus replication and transcription activator protein activates CD274/PD‐L1 gene promoter
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DOI: 10.1111/cas.15673
Abstract: Kaposi's sarcoma–associated herpesvirus (KSHV) is responsible for the pathogenesis of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman disease. The expression of immunosuppressive genes, such as IL‐10 and CD274/PD‐L1 is observed during KSHV‐associated pathogenesis, and… read more here.
Keywords: promoter; kaposi sarcoma; associated herpesvirus; cd274 gene ... See more keywords
Conserved CxnC Motifs in Kaposi’s Sarcoma-Associated Herpesvirus ORF66 Are Required for Viral Late Gene Expression and Are Essential for Its Interaction with ORF34
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DOI: 10.1128/jvi.01299-19
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV; human herpesvirus 8) is an oncogenic gammaherpesvirus that is the causative agent of multiple human cancers. The release of infectious virions requires the production of capsid proteins and other late genes,… read more here.
Keywords: sarcoma associated; late gene; kaposi sarcoma; associated herpesvirus ... See more keywords
Upregulation of ATF4-LAMP3 Axis by ORF45 Facilitates Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus
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DOI: 10.1128/jvi.01456-22
Abstract: The lytic replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) reprograms cellular transcription and translation to generate viral proteins and virion particles. Here, we show that the mediator of ER stress ATF4 and the expression of the… read more here.
Keywords: lytic replication; replication; lamp3; kaposi sarcoma ... See more keywords
Structure of the Kaposi’s sarcoma-associated herpesvirus gB in post-fusion conformation
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DOI: 10.1128/jvi.01533-24
Abstract: ABSTRACT Discovered in 1994 in lesions of an AIDS patient, Kaposi’s sarcoma-associated herpesvirus (KSHV) is a member of the gammaherpesvirus subfamily of the Herpesviridae family, which contains a total of nine that infect humans. These… read more here.
Keywords: structure; kshv; associated herpesvirus; kaposi sarcoma ... See more keywords