Gene editing of NCF1 loci is associated with homologous recombination and chromosomal rearrangements
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-06959-z
Abstract: CRISPR-based genome editing of pseudogene-associated disorders, such as p47phox-deficient chronic granulomatous disease (p47 CGD), is challenged by chromosomal rearrangements due to presence of multiple targets. We report that interactions between highly homologous sequences that are… read more here.
Keywords: recombination; chromosomal rearrangements; recombination chromosomal; associated homologous ... See more keywords
LC3B drives transcription-associated homologous recombination via direct interaction with R-loops
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae156
Abstract: Abstract Exploring the connection between ubiquitin-like modifiers (ULMs) and the DNA damage response (DDR), we employed several advanced DNA damage and repair assay techniques and identified a crucial role for LC3B. Notably, its RNA recognition… read more here.
Keywords: interaction; associated homologous; homologous recombination; transcription associated ... See more keywords