Incidence, Presentation and Risk Factors for Sodium Valproate-Associated Hyperammonemia in Neurosurgical Patients: A Prospective Observational Study.
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DOI: 10.1016/j.wneu.2020.09.027
Abstract: OBJECTIVE Sodium valproate (VPA) is a commonly prescribed antiepileptic drug (AED) in daily neurosurgical practice. However, the incidence of VPA-associated hyperammonemia (VAH) and its life-threatening consequence, VPA-induced hyperammonemic encephalopathy (VHE), in neurosurgical patients is unknown.… read more here.
Keywords: neurosurgical patients; vpa; associated hyperammonemia; presentation risk ... See more keywords
Valproic Acid–Associated Hyperammonemia
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DOI: 10.1097/jcp.0000000000001689
Abstract: Abstract Background Hyperammonemia is an adverse effect that poses clinical uncertainty around valproic acid (VPA) use. The prevalence of symptomatic and asymptomatic hyperammonemia and its relationship to VPA concentration is not well established. There is… read more here.
Keywords: acid associated; vpa; associated hyperammonemia; valproic acid ... See more keywords