Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism
Sign Up to like & getrecommendations! Published in 2020 at "Brain"
DOI: 10.1093/brain/awaa246
Abstract: Parkin/PINK1 deficiency impairs mitophagy in mice, leading to the release of mitochondrial DNA (mtDNA) and triggering inflammation. Borsche et al. now demonstrate elevated serum Interleukin 6 and circulating cell-free mtDNA also in patients with Parkin/PINK1… read more here.
Keywords: mitochondrial damage; inflammation highlights; highlights biomarkers; inflammation ... See more keywords
Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors
Sign Up to like & getrecommendations! Published in 2018 at "Mediators of Inflammation"
DOI: 10.1155/2018/8261432
Abstract: Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic β-cell dysfunction as important hallmarks. Recent evidence indicates that the chronic,… read more here.
Keywords: metabolic disease; inflammation; regulation metabolic; associated inflammation ... See more keywords
Saroglitazar ameliorates monosodium glutamate-induced obesity and associated inflammation in Wistar rats: Plausible role of NLRP3 inflammasome and NF- κB
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.64041.14102
Abstract: Objective(s): Inflammation is the major progenitor of obesity and associated metabolic disorders. The current study investigated the modulatory role of saroglitazar on adipocyte dysfunction and associated inflammation in monosodium glutamate (MSG) obese Wistar rats. Materials… read more here.
Keywords: inflammation; msg; associated inflammation; wistar rats ... See more keywords
O-GlcNAcylation and Its Role in Cancer-Associated Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.861559
Abstract: Cancer cells, as well as surrounding stromal and inflammatory cells, form an inflammatory tumor microenvironment (TME) to promote all stages of carcinogenesis. As an emerging post-translational modification (PTM) of serine and threonine residues of proteins,… read more here.
Keywords: cancer; role; associated inflammation; cancer associated ... See more keywords
Obesity-Associated Inflammation: Does Curcumin Exert a Beneficial Role?
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DOI: 10.3390/nu13031021
Abstract: Curcumin is a lipophilic polyphenol, isolated from the plant turmeric of Curcuma longa. Curcuma longa has always been used in traditional medicine in Asian countries because it is believed to have numerous health benefits. Nowadays… read more here.
Keywords: inflammation; obesity associated; associated inflammation; adipose tissue ... See more keywords
Superficial Venous-Associated Inflammation from Direct IV Administration of RRx-001 in Rats
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Medical Sciences"
DOI: 10.7150/ijms.76615
Abstract: RRx-001 is a small molecule NLRP3 inflammasome inhibitor with anti-CD47 and antiangiogenic/vascular normalization properties in a Phase 3 clinical trial that has been designated as a drug-device combination by the FDA. In the Phase 1… read more here.
Keywords: superficial venous; administration; venous associated; associated inflammation ... See more keywords