OMIP 082: A 25‐color phenotyping to define human innate lymphoid cells, natural killer cells, mucosal‐associated invariant T cells, and γδ T cells from freshly isolated human intestinal tissue
Sign Up to like & getrecommendations! Published in 2022 at "Cytometry Part A"
DOI: 10.1002/cyto.a.24529
Abstract: We developed a 25‐color flow cytometry panel to comprehensively interrogate innate lymphoid cells (ILC), mucosal‐associated invariant T (MAIT) cells, natural killer (NK) cells and γδ T cells in human tissues. The ability to isolate and… read more here.
Keywords: cells natural; mucosal associated; associated invariant; innate lymphoid ... See more keywords
Th1 bias of liver mucosal‐associated invariant T cells promotes hepatic gluconeogenesis in type 2 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2023 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3620
Abstract: It is acknowledged that aberrant liver immunity contributes to the development of type 2 diabetes mellitus (T2DM). Mucosal‐associated invariant T (MAIT) cells, an innate‐like T‐cell subset, are enriched in the human liver. Nevertheless, the characterisation… read more here.
Keywords: liver; mucosal associated; associated invariant; type diabetes ... See more keywords
TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.08.054
Abstract: Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor (TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin biosynthesis, or via cytokines. These two modes of activation may act in concert… read more here.
Keywords: tcr cytokine; mait cells; associated invariant; immune responses ... See more keywords
Mucosal-Associated Invariant T Cells Redistribute to the Peritoneal Cavity During Spontaneous Bacterial Peritonitis and Contribute to Peritoneal Inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2020.01.003
Abstract: Background & Aims Mucosal-associated invariant T (MAIT) cells are depleted from blood in patients with advanced liver disease and show features of immune dysfunction. Because circulating MAIT cells differ from organ-resident MAIT cells, we aimed… read more here.
Keywords: associated invariant; mait cells; peritoneal mait; mait ... See more keywords
Corrigendum to “Representations of ⁎-semigroups associated to invariant kernels with values adjointable operators” [Linear Algebra Appl. 486 (2015) 361–388]
Sign Up to like & getrecommendations! Published in 2020 at "Linear Algebra and its Applications"
DOI: 10.1016/j.laa.2020.01.009
Abstract: Abstract We correct a lemma by adding the assumption that the ordered ⁎-space is Archimedean and show by counter-examples and examples that this is needed. read more here.
Keywords: semigroups associated; representations semigroups; associated invariant; invariant kernels ... See more keywords
MR1 Restricted Mucosal-Associated Invariant T (MAIT) Cells Respond to Mycobacterial Vaccination and Infection in Nonhuman Primates
Sign Up to like & getrecommendations! Published in 2017 at "Mucosal immunology"
DOI: 10.1038/mi.2016.91
Abstract: Studies on mucosal-associated invariant T cells (MAITs) in nonhuman primates (NHP), a physiologically relevant model of human immunity, are handicapped due to a lack of macaque MAIT-specific reagents. Here we show that while MR1 ligand-contact… read more here.
Keywords: associated invariant; mr1; mait; mucosal associated ... See more keywords
Mucosal-associated invariant T cells and disease
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Immunology"
DOI: 10.1038/s41577-019-0191-y
Abstract: Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate and adaptive immunity. They are activated by conserved bacterial ligands derived from vitamin B biosynthesis and have important roles in defence against… read more here.
Keywords: associated invariant; cells disease; mucosal associated; invariant cells ... See more keywords
Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc00247j
Abstract: Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we demonstrate that changes to the 6-aminoalkyl chain on uracil agonist… read more here.
Keywords: mait cell; associated invariant; mait; mucosal associated ... See more keywords
Human mucosal-associated invariant T cells respond to Mucorales species in a MR1-dependent manner.
Sign Up to like & getrecommendations! Published in 2020 at "Medical mycology"
DOI: 10.1093/mmy/myaa103
Abstract: Activation of mucosal-associated invariant T cells (MAIT cells) by certain bacteria, viruses, and yeast is well studied, but the activation potential of filamentous moulds from the order Mucorales is not known. Here, we show a… read more here.
Keywords: mucorales species; associated invariant; mucosal associated; activation ... See more keywords
Persistent deficiency of mucosal-associated invariant T cells during dermatomyositis.
Sign Up to like & getrecommendations! Published in 2019 at "Rheumatology"
DOI: 10.1093/rheumatology/kez564
Abstract: OBJECTIVES Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that are important for antibacterial immunity and may have regulatory roles. MAIT cells are decreased during SLE. However, their frequencies and phenotype have not been investigated… read more here.
Keywords: healthy controls; mait cells; associated invariant; mait ... See more keywords
The frequency of mucosal‐associated invariant T cells is selectively increased in dermatitis herpetiformis
Sign Up to like & getrecommendations! Published in 2017 at "Australasian Journal of Dermatology"
DOI: 10.1111/ajd.12456
Abstract: Mucosal‐associated invariant T (MAIT) cells are a novel subset of innate‐like T‐cells that are enriched in mucosal tissues. Their presence in human skin has only recently been recognised. We describe the expression of skin‐tropic molecules… read more here.
Keywords: associated invariant; frequency mucosal; mucosal associated; mucosal ... See more keywords