Combined metformin-associated lactic acidosis and euglycemic ketoacidosis
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DOI: 10.1007/s00508-017-1251-6
Abstract: SummaryBackgroundIn renal failure metformin can lead to lactic acidosis. Additional inhibition of hepatic gluconeogenesis by accumulation of the drug may aggravate fasting-induced ketoacidosis. We report the occurrence of metformin-associated lactic acidosis (MALA) with concurrent euglycemic… read more here.
Keywords: metformin associated; lactic acidosis; ketoacidosis; associated lactic ... See more keywords
The Association between Metformin Therapy and Lactic Acidosis
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DOI: 10.1007/s40264-019-00854-x
Abstract: There is increasing evidence to suggest that therapeutic doses of metformin are unlikely to cause lactic acidosis. The aims of this research were (1) to formally evaluate the association between metformin therapy and lactic acidosis… read more here.
Keywords: acidosis; metformin associated; lactic acidosis; association ... See more keywords
Expanding the evidence for managing metformin poisoning to support decision-making
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DOI: 10.1080/15563650.2023.2196372
Abstract: Abstract Introduction Metformin-associated lactic acidosis is a well-described and commonly encountered condition associated with significant morbidity and mortality. Patients with metformin-associated lactic acidosis are frequently managed in the intensive care unit with supportive care, including… read more here.
Keywords: metformin associated; extracorporeal treatments; associated lactic; extracorporeal treatment ... See more keywords
Metformin-Associated Lactic Acidosis Undergoing Renal Replacement Therapy in Intensive Care Units: A Five-Million Population-Based Study in the North-West of Italy
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DOI: 10.1159/000471917
Abstract: Background: Metformin-associated lactic acidosis (MALA) is a severe complication of drug administration with significant morbidity and mortality. So far no study in large population areas have examined the incidence, clinical profile and outcome of acute… read more here.
Keywords: metformin associated; lactic acidosis; metformin; intensive care ... See more keywords
Achieving High Dialysis Dose via Continuous Renal Replacement Therapy in the Setting of Metformin Associated Lactic Acidosis. A Case Series
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DOI: 10.1213/xaa.0000000000001561
Abstract: Severe and life-threatening cases of metformin-associated lactic acidosis (MALA) are treated with renal replacement therapy. Intermittent hemodialysis is recommended, as it achieves rapid more elimination of metformin compared to continuous renal replacement therapy (CRRT). This… read more here.
Keywords: associated lactic; renal replacement; replacement therapy; metformin associated ... See more keywords