Evidence of Polygenic Adaptation in Sardinia at Height-Associated Loci Ascertained from the Biobank Japan.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2020.05.014
Abstract: Adult height is one of the earliest putative examples of polygenic adaptation in humans. However, this conclusion was recently challenged because residual uncorrected stratification from large-scale consortium studies was considered responsible for the previously noted… read more here.
Keywords: loci; associated loci; polygenic adaptation; height associated ... See more keywords
Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control.
Sign Up to like & getrecommendations! Published in 2020 at "Human molecular genetics"
DOI: 10.1093/hmg/ddaa013
Abstract: High serum urate is a prerequisite for gout and associated with metabolic disease. Genome-wide association studies (GWAS) have reported dozens of loci associated with serum urate control, however there has been little progress in understanding… read more here.
Keywords: serum urate; associated loci; urate control; serum ... See more keywords
Defining novel causal SNPs and linked phenotypes at melanoma-associated loci
Sign Up to like & getrecommendations! Published in 2022 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddac074
Abstract: Abstract A number of genomic regions have been associated with melanoma risk through genome-wide association studies; however, the causal variants underlying the majority of these associations remain unknown. Here, we sequenced either the full locus… read more here.
Keywords: loci; melanoma; melanoma risk; associated loci ... See more keywords
Modelling the genetic aetiology of complex disease: human–mouse conservation of noncoding features and disease-associated loci
Sign Up to like & getrecommendations! Published in 2022 at "Biology Letters"
DOI: 10.1098/rsbl.2021.0630
Abstract: Understanding the genetic aetiology of loci associated with a disease is crucial for developing preventative measures and effective treatments. Mouse models are used extensively to understand human pathobiology and mechanistic functions of disease-associated loci. However,… read more here.
Keywords: complex disease; disease; associated loci; genetic aetiology ... See more keywords
Genomewide association analyses of fitness traits in captive‐reared Chinook salmon: Applications in evaluating conservation strategies
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DOI: 10.1111/eva.12599
Abstract: A novel application of genomewide association analyses is to use trait‐associated loci to monitor the effects of conservation strategies on potentially adaptive genetic variation. Comparisons of fitness between captive‐ and wild‐origin individuals, for example, do… read more here.
Keywords: associated loci; trait associated; conservation; genomewide association ... See more keywords
Discovery and Replication of HDL-Associated Loci in the Korean Population Using 35,000 Individuals
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DOI: 10.2337/db18-216-lb
Abstract: Low levels of HDL are known to be associated with increased risk of type 2 diabetes. It has been suggested as a new therapeutic approach that increase HDL levels in plasma. Previously, to identify lipids… read more here.
Keywords: associated loci; study; hdl; using 000 ... See more keywords
Evaluation of Male Fertility-Associated Loci in a European Population of Patients with Severe Spermatogenic Impairment
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DOI: 10.3390/jpm11010022
Abstract: Infertility is a growing concern in developed societies. Two extreme phenotypes of male infertility are non-obstructive azoospermia (NOA) and severe oligospermia (SO), which are characterized by severe spermatogenic failure (SpF). We designed a genetic association… read more here.
Keywords: associated loci; fertility associated; evaluation male; severe spermatogenic ... See more keywords