Mitochondria-associated membranes (MAMs): An emerging platform connecting energy and immune sensing to metabolic flexibility.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.097
Abstract: Living organisms have the capacity to sense both nutrients and immune signals in order to adapt their metabolism to the needs, and both metabolic inflexibility and exacerbated immune responses are associated with metabolic diseases. Over… read more here.
Keywords: immune; metabolic diseases; mitochondria associated; associated membranes ... See more keywords
Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.073
Abstract: Stasimon (also known as Tmem41b) is an evolutionarily conserved transmembrane protein first identified for its contribution to motor system dysfunction in animal models of the childhood neurodegenerative disease spinal muscular atrophy (SMA). Stasimon was shown… read more here.
Keywords: localizes mitochondria; embryonic development; mitochondria associated; associated membranes ... See more keywords
PACS: 2: A Key Regulator of Mitochondria-Associated Membranes (MAMs).
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105080
Abstract: Mitochondria-associated membranes (MAMs) are the organellar contact sites between mitochondria and the endoplasmic reticulum (ER), and recent studies demonstrated that MAMs, which serve as multiple scaffolds of proteins, are involved in Ca2+ signaling, lipid metabolism,… read more here.
Keywords: mitochondria associated; associated membranes; pacs key; membranes mams ... See more keywords
CLIC4 localizes to mitochondrial-associated membranes and mediates cardioprotection
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo1244
Abstract: Mitochondrial-associated membranes (MAMs) are known to modulate organellar and cellular functions and can subsequently affect pathophysiology including myocardial ischemia-reperfusion (IR) injury. Thus, identifying molecular targets in MAMs that regulate the outcome of IR injury will… read more here.
Keywords: localizes mitochondrial; mitochondrial associated; clic4; injury ... See more keywords
Identifying mitotane-induced mitochondria-associated membranes dysfunctions: metabolomic and lipidomic approaches
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18968
Abstract: Mitotane (o,p’DDD), the most effective drug in adrenocortical carcinoma, concentrates into the mitochondria and impacts mitochondrial functions. To address the molecular mechanisms of mitotane action and to identify its potential target, metabolomic and lipidomic approaches… read more here.
Keywords: lipidomic approaches; mitotane; mitochondria associated; mitotane induced ... See more keywords
Evaluation of Parkin in the Regulation of Myocardial Mitochondria-Associated Membranes and Cardiomyopathy During Endotoxemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.796061
Abstract: Background: Mitochondrial deficiency is a known pathology in sepsis-induced organ failure. We previously found that mitochondria-associated membranes (MAMs), a subcellular domain supporting mitochondrial status, are impaired in the heart during endotoxemia, suggesting a mechanism of… read more here.
Keywords: function; regulation; parkin; mutation ... See more keywords
The role of mitochondria-associated membranes mediated ROS on NLRP3 inflammasome in cardiovascular diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1059576
Abstract: Reactive oxygen species (ROS) metabolism is essential for the homeostasis of cells. Appropriate production of ROS is an important signaling molecule, but excessive ROS production can damage cells. ROS and ROS-associated proteins can act as… read more here.
Keywords: inflammasome cardiovascular; cardiovascular diseases; mediated ros; associated membranes ... See more keywords
A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12030414
Abstract: Simple Summary Neurodegenerative diseases affect millions of people worldwide, and their prevalence rises dramatically with age. Although a few therapeutic options help to relieve symptoms associated with these disorders, slowing their progression is not presently… read more here.
Keywords: metabolism; lipid droplets; neurodegenerative diseases; associated membranes ... See more keywords