Elucidating tumour‐associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13287
Abstract: In glioblastoma (GBM), tumour‐associated microglia/macrophages (TAMs) represent the major cell type of the stromal compartment and contribute to tumour immune escape mechanisms. Thus, targeting TAMs is emerging as a promising strategy for immunotherapy. However, TAM… read more here.
Keywords: associated microglia; microglia macrophage; progression; tumour ... See more keywords
Gender differences in Alzheimer's may be associated with TLR4-LYN expression in damage associated microglia and neuronal phagocytosis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30916
Abstract: The role of Aβ plaques and neurofibrillary tangles in Alzheimer's disease (AD) pathogenesis have recently come into question due to failure of many pharmaceutical agents targeting these deposits and detection of these misfolded proteins in… read more here.
Keywords: tlr4; associated microglia; phagocytosis; tlr4 lyn ... See more keywords
PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202201467
Abstract: PRMT1 regulates MHC-associated microglia cluster during de/remyelination. Remyelination failure in multiple sclerosis leads to progressive demyelination and inflammation, resulting in neurodegeneration and clinical decline. Microglia are innate immune cells that can acquire a regenerative phenotype… read more here.
Keywords: remyelination; associated microglia; central nervous; prmt1 ... See more keywords
Tumor-associated microglia and macrophages in glioblastoma: From basic insights to therapeutic opportunities
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.964898
Abstract: Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. Currently, the standard treatment of glioblastoma includes surgery, radiotherapy, and chemotherapy. Despite aggressive treatment, the median survival is only 15 months. GBM… read more here.
Keywords: associated microglia; glioblastoma basic; macrophages glioblastoma; microglia macrophages ... See more keywords
Pial Vessel-Associated Microglia/Macrophages Increase in Female Dahl-SS/Jr Rats Independent of Pregnancy History
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23063384
Abstract: As the resident immune cells of the central nervous system, microglia have a wide range of functions such as surveillance, phagocytosis, and signaling through production of chemokines and cytokines. Recent studies have identified and characterized… read more here.
Keywords: vessel associated; associated microglia; microglia macrophages; pregnancy history ... See more keywords