Elucidating tumour‐associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13287
Abstract: In glioblastoma (GBM), tumour‐associated microglia/macrophages (TAMs) represent the major cell type of the stromal compartment and contribute to tumour immune escape mechanisms. Thus, targeting TAMs is emerging as a promising strategy for immunotherapy. However, TAM… read more here.
Keywords: associated microglia; microglia macrophage; progression; tumour ... See more keywords
Gender differences in Alzheimer's may be associated with TLR4-LYN expression in damage associated microglia and neuronal phagocytosis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30916
Abstract: The role of Aβ plaques and neurofibrillary tangles in Alzheimer's disease (AD) pathogenesis have recently come into question due to failure of many pharmaceutical agents targeting these deposits and detection of these misfolded proteins in… read more here.
Keywords: tlr4; associated microglia; phagocytosis; tlr4 lyn ... See more keywords
EPCO-34. GBM GROWTH MODE IS GOVERNED BY EPIGENETIC REPROGRAMMING OF TUMOR-ASSOCIATED MICROGLIA
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.0034
Abstract: The invasive nature of glioblastoma (GBM), the most common malignant primary brain tumor, makes it complete resection impossible. Microglia, the brain’s resident immune cells, typically contribute to neural homeostasis, but their role in regulating GBM… read more here.
Keywords: gbm; tumor associated; tumor; associated microglia ... See more keywords
IMMU-17. Vessel-Associated Microglia Maintain Vascular Integrity and Prevent Early Hemorrhage in Glioblastoma
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.0816
Abstract: Aberrant vasculature is a hallmark of glioblastoma (GBM), contributing to both blood–brain barrier (BBB) dysfunction and frequent intracranial hemorrhage. Myeloid cells, including microglia and macrophages, are known to co-opt tumor vasculature during tumor progression, but… read more here.
Keywords: mice; tumor; hemorrhage; associated microglia ... See more keywords
Abstract 3991: A neural organoid glioblastoma model to assess tumor microenvironment interactions and tumor associated microglia and macrophage responses
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3991
Abstract: Glioblastoma (GBM) is a treatment resistant brain tumor with a median survival post-diagnosis of only 18-20 months. One significant limitation in the development of effective therapeutics for GBM is the lack of suitable pre-clinical models… read more here.
Keywords: tumor microenvironment; tumor associated; gbm; tumor ... See more keywords
Tmem119 expression is downregulated in a subset of brain metastasis-associated microglia
Sign Up to like & getrecommendations! Published in 2024 at "BMC Neuroscience"
DOI: 10.1186/s12868-024-00846-3
Abstract: Under pathological conditions, the immune-specialized brain microenvironment contains both resident microglia and bone marrow-derived myeloid cells recruited from peripheral circulation. Due to largely overlapping phenotypic similarities between these ontogenically distinct myeloid populations, studying their individual… read more here.
Keywords: expression; tmem119 expression; associated microglia; metastasis associated ... See more keywords
Rod-shaped microglia represent a morphologically distinct subpopulation of disease-associated microglia
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-025-03504-5
Abstract: Microglia, resident immune cells of the central nervous system, play an essential role in responding to pathological conditions by adopting diverse activation states and morphologies. Recent single-cell RNA sequencing have revealed that microglial subtypes were… read more here.
Keywords: associated microglia; shaped microglia; disease associated; rod shaped ... See more keywords
Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma
Sign Up to like & getrecommendations! Published in 2024 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-024-01754-7
Abstract: Tumor-associated microglia and blood-derived macrophages (TAMs) play a central role in modulating the immune suppressive microenvironment in glioma. Here, we show that GPNMB is predominantly expressed by TAMs in human glioblastoma multiforme and the murine… read more here.
Keywords: tumor associated; tumor; immune cell; associated microglia ... See more keywords
PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202201467
Abstract: PRMT1 regulates MHC-associated microglia cluster during de/remyelination. Remyelination failure in multiple sclerosis leads to progressive demyelination and inflammation, resulting in neurodegeneration and clinical decline. Microglia are innate immune cells that can acquire a regenerative phenotype… read more here.
Keywords: remyelination; associated microglia; central nervous; prmt1 ... See more keywords
Tumor-associated microglia and macrophages in glioblastoma: From basic insights to therapeutic opportunities
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.964898
Abstract: Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. Currently, the standard treatment of glioblastoma includes surgery, radiotherapy, and chemotherapy. Despite aggressive treatment, the median survival is only 15 months. GBM… read more here.
Keywords: associated microglia; glioblastoma basic; macrophages glioblastoma; microglia macrophages ... See more keywords
Pial Vessel-Associated Microglia/Macrophages Increase in Female Dahl-SS/Jr Rats Independent of Pregnancy History
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23063384
Abstract: As the resident immune cells of the central nervous system, microglia have a wide range of functions such as surveillance, phagocytosis, and signaling through production of chemokines and cytokines. Recent studies have identified and characterized… read more here.
Keywords: vessel associated; associated microglia; microglia macrophages; pregnancy history ... See more keywords