Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.08.018
Abstract: We have recently reported that a short course of morphine, starting 10days after sciatic chronic constriction injury (CCI), prolonged the duration of mechanical allodynia for months after morphine ceased. Maintenance of this morphine-induced persistent sensitization… read more here.
Keywords: associated molecular; morphine; nlrp3 inflammasomes; molecular patterns ... See more keywords
DANGER SIGNALS IN LIVER INJURY AND RESTORATION OF HOMEOSTASIS.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2020.04.033
Abstract: Damage-associated molecular patterns are signaling molecules involved in inflammatory responses and restoration of homeostasis. Chronic release of these molecules can also promote inflammation, including in the context of liver disease. This comprehensive summary describes the… read more here.
Keywords: associated molecular; liver; molecular patterns; damage associated ... See more keywords
Plasma-synthesized mussel-inspired gold nanoparticles promote autophagy-dependent damage-associated molecular pattern release to potentiate immunogenic cancer cell death
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Industrial and Engineering Chemistry"
DOI: 10.1016/j.jiec.2021.05.035
Abstract: Abstract The development of an efficient tumor-specific therapeutic approach, which functions against the primary tumor and also repairs the host immune system to eradicate distant tumors, remains a clinical issue. Herein, this study focuses on… read more here.
Keywords: cell death; pda nps; associated molecular; damage associated ... See more keywords
ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-59444-4
Abstract: The giant E3 ubiquitin ligase RNF213 is a conserved component of mammalian cell-autonomous immunity, limiting the replication of bacteria, viruses and parasites. To understand how RNF213 reacts to these unrelated pathogens, we employ chemical and… read more here.
Keywords: pathogen associated; ubiquitin ligase; ligase rnf213; associated molecular ... See more keywords
Damage-associated molecular patterns and their role as initiators of inflammatory and auto-immune signals in systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2017 at "International Reviews of Immunology"
DOI: 10.1080/08830185.2017.1365146
Abstract: ABSTRACT Damage-associated molecular patterns (DAMPs) are endogenous molecules that are released into the extracellular space under conditions of activation, cellular stress, or tissue damage. These molecules are recognized by pattern-recognition receptors (PRRs) and can induce… read more here.
Keywords: auto; associated molecular; molecular patterns; auto immune ... See more keywords
Danger Signals in the ICU
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000003007
Abstract: Objectives: Sterile and infectious critical illnesses often result in vasoplegic shock and a robust systemic inflammatory response that are similar in presentation. The innate immune system is at the center of the response to both… read more here.
Keywords: associated molecular; response; molecular patterns; damage associated ... See more keywords
Regulatory T cells, damage-associated molecular patterns, and myeloid-derived suppressor cells in bronchoalveolar lavage fluid interlinked with chronic obstructive pulmonary disease severity
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029208
Abstract: Abstract The role of regulatory T cells (Tregs), damage-associated molecular patterns (DAMPs), and myeloid-derived suppressor cells (MDSCs) in the mechanism of innate and adaptive immune responses in chronic obstructive pulmonary disease (COPD) is not well… read more here.
Keywords: regulatory cells; damage associated; myeloid derived; disease ... See more keywords
BACTERIAL PATHOGEN–ASSOCIATED MOLECULAR PATTERNS UPREGULATE HUMAN GLUCOCORTICOID RECEPTOR EXPRESSION IN PERIPHERAL BLOOD MONONUCLEAR CELLS
Sign Up to like & getrecommendations! Published in 2022 at "Shock"
DOI: 10.1097/shk.0000000000002004
Abstract: ABSTRACT It is well known that bacterial components (pathogen-associated molecular patterns [PAMPs]) induce a proinflammatory response through pattern recognition receptor signaling. What is not known, however, is how the inflammatory response is downregulated. We hypothesize… read more here.
Keywords: molecular patterns; expression; hgr; associated molecular ... See more keywords
NEUTROPHIL HETEROGENEITY IN SEPSIS: THE ROLE OF DAMAGE-ASSOCIATED MOLECULAR PATTERNS
Sign Up to like & getrecommendations! Published in 2022 at "Shock"
DOI: 10.1097/shk.0000000000002019
Abstract: ABSTRACT Sepsis is a severe inflammatory disease syndrome caused by the dysregulated host response to infection. Neutrophils act as the first line of defense against pathogens by releasing effector molecules such as reactive oxygen species,… read more here.
Keywords: sepsis; heterogeneity; damage associated; damage ... See more keywords
Cellulose-Derived Oligomers Act as Damage-Associated Molecular Patterns and Trigger Defense-Like Responses1
Sign Up to like & getrecommendations! Published in 2017 at "Plant Physiology"
DOI: 10.1104/pp.16.01680
Abstract: Cellobiose, a danger signal derived from breakdown of the major cell wall polymer cellulose, enhances plant defenses triggered by microbe-derived elicitors. The plant cell wall, often the site of initial encounters between plants and their… read more here.
Keywords: associated molecular; plant; molecular patterns; damage associated ... See more keywords
Mitochondrial damage–associated molecular patterns released by lung transplants are associated with primary graft dysfunction
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Transplantation"
DOI: 10.1111/ajt.15232
Abstract: Primary graft dysfunction (PGD) is a major limitation in short‐ and long‐term lung transplant survival. Recent work has shown that mitochondrial damage–associated molecular patterns (mtDAMPs) can promote solid organ injury, but whether they contribute to… read more here.
Keywords: mitochondrial damage; associated molecular; graft dysfunction; damage associated ... See more keywords