Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules.
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DOI: 10.1016/j.joca.2016.08.012
Abstract: OBJECTIVE To evaluate the anti-inflammatory mechanism of action of Chondroitin Sulphate (CS). DESIGN THP-1 macrophages were cultured with a range of sizes and concentrations of HA fragments with TLR4 (LPS in a physiologically relevant concentration… read more here.
Keywords: chondroitin sulphate; associated molecules; activity induced; damage associated ... See more keywords
Analysis of PI3K Pathway Associated Molecules Reveals Dysregulated Innate and Adaptive Functions of B Cells in Early Diffuse Cutaneous Systemic Sclerosis
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DOI: 10.3390/ijms22062877
Abstract: B cell activation is an early event in the development of systemic sclerosis (SSc). The classical activation of B cells downstream of the B-cell receptor (BCR) involves the phosphatidylinositol-3 kinase (PI3K) pathway that integrates the… read more here.
Keywords: associated molecules; systemic sclerosis; analysis pi3k; activation ... See more keywords
Activated PyK2 and Its Associated Molecules Transduce Cellular Signaling from the Cancerous Milieu for Cancer Metastasis
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DOI: 10.3390/ijms232415475
Abstract: PyK2 is a member of the proline-rich tyrosine kinase and focal adhesion kinase families and is ubiquitously expressed. PyK2 is mainly activated by stimuli, such as activated Src kinases and intracellular acidic pH. The mechanism… read more here.
Keywords: pyk2; associated molecules; cancer metastasis; milieu ... See more keywords