Role of cardiac MRI in the diagnosis of immune checkpoint inhibitor‐associated myocarditis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34169
Abstract: Immune checkpoint inhibitor (ICI)‐induced cardiotoxicity is a rare immune‐related adverse event (irAE) characterized by a high mortality rate. From a pathological point of view, this condition can result from a series of causes, including binding… read more here.
Keywords: myocarditis; checkpoint inhibitor; immune checkpoint; diagnosis ... See more keywords
Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation
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DOI: 10.1038/s41467-024-50996-5
Abstract: Immune checkpoint inhibitor (ICI)-induced myocarditis involves intensive immune/inflammation activation; however, its molecular basis is unclear. Here, we show that gasdermin-E (GSDME), a gasdermin family member, drives ICI-induced myocarditis. Pyroptosis mediated by GSDME, but not the… read more here.
Keywords: activation; ici induced; induced myocarditis; myocarditis ... See more keywords
Potential of Heparin in the Treatment of COVID-19–Associated Myocarditis
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Emergency Care"
DOI: 10.1097/pec.0000000000002645
Abstract: To the Editors: W e read with great interest an article in your journal about the evaluation of COVID-19–associated myocarditis. As far as we know, COVID-19 is an infectious disease characterized by respiratory symptoms that… read more here.
Keywords: treatment; potential heparin; covid associated; heparin ... See more keywords
Successful rechallenge after clozapine-associated myocarditis
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Case Reports"
DOI: 10.1136/bcr-2022-248909
Abstract: Clozapine is a highly effective medication used in management of treatment-resistant schizophrenia. Clozapine-associated myocarditis (CAM) is a rare but increasingly recognised complication of clozapine titration. Following an episode of CAM, clinicians can face a challenging… read more here.
Keywords: clozapine associated; rechallenge clozapine; clozapine; associated myocarditis ... See more keywords
Myocardial Injury Pattern at MRI in COVID-19 Vaccine–Associated Myocarditis
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DOI: 10.1148/radiol.212559
Abstract: Background There are limited data on the pattern and severity of myocardial injury in patients with COVID-19 vaccination–associated myocarditis. Purpose To describe myocardial injury following COVID-19 vaccination and to compare these findings to other causes… read more here.
Keywords: myocarditis; myocardial injury; vaccine associated; covid vaccination ... See more keywords
Abstract 4358585: Hemodynamic Subtypes of Pulmonary Hypertension Based on Right Heart Catheterization Data Predict Outcomes in ICI-Associated Myocarditis
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4358585
Abstract: Background: Pulmonary hypertension (PH) is a known complication in patients with cancer, arising from both therapies and malignancies. Immune checkpoint inhibitor (ICI)-associated myocarditis has been linked to PH in case reports, but its impact on… read more here.
Keywords: pre capillary; post capillary; mmhg; ici associated ... See more keywords
Vaccination-Associated Myocarditis and Myocardial Injury
Sign Up to like & getrecommendations! Published in 2023 at "Circulation Research"
DOI: 10.1161/circresaha.122.321881
Abstract: SARS-CoV-2 vaccine–associated myocarditis/myocardial injury should be evaluated in the contexts of COVID-19 infection, other types of viral myocarditis, and other vaccine-associated cardiac disorders. COVID-19 vaccine–associated myocardial injury can be caused by an inflammatory immune cell… read more here.
Keywords: myocarditis; associated myocarditis; vaccine associated; myocardial injury ... See more keywords
Cardiac myosin-specific autoimmune T cells contribute to immune-checkpoint-inhibitor-associated myocarditis.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.2139/ssrn.4065075
Abstract: Immune checkpoint inhibitors (ICIs) are an effective therapy for various cancers; however, they can induce immune-related adverse events (irAEs) as a side effect. Myocarditis is an uncommon, but fatal, irAE caused after ICI treatments. Currently,… read more here.
Keywords: myocarditis; cardiac myosin; immune checkpoint; myosin specific ... See more keywords
Cardiac magnetic resonance follow-up of COVID-19 vaccine associated acute myocarditis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1049256
Abstract: Background Mass COVID-19 vaccination campaigns have helped impede the COVID-19 pandemic. In rare cases, some vaccines have led to vaccine associated myocarditis in a specific subset of the population, usually young males. Cardiac magnetic resonance… read more here.
Keywords: myocarditis; acute myocarditis; vaccine associated; cardiac magnetic ... See more keywords
Multi-organ Immune-Related Adverse Event Is a Risk Factor of Immune Checkpoint Inhibitor-Associated Myocarditis in Cancer Patients: A Multi-center Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.879900
Abstract: Background and Objective Immune checkpoint inhibitor (ICI)-associated myocarditis is a fatal immune-related adverse events (irAEs), which is prone to affecting multiple organ systems. Multi-organ irAEs have not been fully studied in ICI-associated myocarditis. Therefore, we… read more here.
Keywords: myocarditis; multi organ; risk factor; organ iraes ... See more keywords
Case Report: Two cases of immune-associated myocarditis caused by tislelizumab
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2025.1549141
Abstract: The current phase of immune checkpoint inhibitors has improved the clinical outcomes of many cancer therapies; however, these agents may also lead to some high-consequence immune-related adverse events. We report two cases of cancer patients… read more here.
Keywords: report two; immune associated; two cases; associated myocarditis ... See more keywords