HIV Tat causes synapse loss in a mouse model of HIV‐associated neurocognitive disorder that is independent of the classical complement cascade component C1q
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DOI: 10.1002/glia.23511
Abstract: Microglial activation, increased proinflammatory cytokine production, and a reduction in synaptic density are key pathological features associated with HIV‐associated neurocognitive disorders (HAND). Even with combination antiretroviral therapy (cART), more than 50% of HIV‐positive individuals experience… read more here.
Keywords: hiv; complement; associated neurocognitive; tat ... See more keywords
The Impact of HIV-Associated Neurocognitive Impairment on Driving Performance in Commercial Truck Drivers
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DOI: 10.1007/s10461-020-03033-7
Abstract: Driving ability can be diminished amongst people with HIV with associated neurocognitive impairment (NCI). We explore the relationship between HIV status, NCI and driving ability in professional truck drivers. Forty male professional drivers (20 HIV-positive;… read more here.
Keywords: neurocognitive impairment; associated neurocognitive; truck drivers; hiv associated ... See more keywords
Childhood maltreatment and HIV-associated neurocognitive disorders share similar pathophysiology: a potential sensitisation mechanism?
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DOI: 10.1007/s11011-017-0062-9
Abstract: AbstractHIV-associated neurocognitive disorders (HAND) are increasingly prevalent despite the use of antiretroviral therapies. Previous research suggests that individual host factors play an important role in determining susceptibility to HAND. In this review, we propose that… read more here.
Keywords: share; childhood; hand; neurocognitive disorders ... See more keywords
Monitoring HIV-Associated Neurocognitive Disorder Using Screenings: a Critical Review Including Guidelines for Clinical and Research Use
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DOI: 10.1007/s11904-017-0349-9
Abstract: Screening tools to identify HIV-associated neurocognitive disorder (HAND) are primarily devised to detect cognitive impairment on a single occasion. With the chronicity of HIV infection and the risk of HAND developing or progressing despite viral… read more here.
Keywords: use; screening tools; neurocognitive disorder; hand ... See more keywords
A mouse model of HIV-associated neurocognitive disorders: a brain-behavior approach to discover disease mechanisms and novel treatments
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DOI: 10.1007/s13365-017-0572-6
Abstract: HIV-associated neurocognitive disorders (HAND) remain highly prevalent despite combined antiretroviral therapy (cART). Although the most common forms of HAND are mild and identified through neuropsychological testing, there is evidence that with aging these mild forms… read more here.
Keywords: hiv; hand; model; neurocognitive disorders ... See more keywords
A candidate gene study of intermediate histopathological phenotypes in HIV-associated neurocognitive disorders
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DOI: 10.1007/s13365-020-00846-z
Abstract: HIV-associated neurocognitive disorders (HAND) describe a spectrum of neuropsychological impairment caused by HIV-1 infection. While the sequence of cellular and physiological events that lead to HAND remains obscure, it likely involves chronic neuroinflammation. Host genetic… read more here.
Keywords: neurocognitive functioning; study; hand; neurocognitive disorders ... See more keywords
TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use.
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DOI: 10.1007/s13365-021-00970-4
Abstract: In the brain, both HIV-1 and methamphetamine (meth) use result in increases in oxidative and nitrosative stress. This redox stress is thought to contribute to the pathogenesis of HIV-associated neurocognitive disorder (HAND) and further worsening… read more here.
Keywords: use; neurocognitive disorder; hiv; tca cycle ... See more keywords
Automated diagnosis of HIV-associated neurocognitive disorders using large-scale Granger causality analysis of resting-state functional MRI
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DOI: 10.1016/j.compbiomed.2019.01.006
Abstract: HIV-associated neurocognitive disorders (HAND) represent an important source of neurologic complications in individuals with HIV. The dynamic, often subclinical, course of HAND has rendered diagnosis, which currently depends on neuropsychometric (NP) evaluation, a challenge for… read more here.
Keywords: large scale; hiv; brain; neurocognitive disorders ... See more keywords
Signatures of HIV-1 subtype B and C Tat proteins and their effects in the neuropathogenesis of HIV-associated neurocognitive impairments
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DOI: 10.1016/j.nbd.2019.104701
Abstract: HIV-associated neurocognitive impairments (HANI) are a spectrum of neurological disorders due to the effects of HIV-1 on the central nervous system (CNS). The HIV-1 subtypes; HIV-1 subtype B (HIV-1B) and HIV-1 subtype C (HIV-1C) are… read more here.
Keywords: hiv; hiv subtype; associated neurocognitive; tat ... See more keywords
Affective symptoms in schizophrenia are strongly associated with neurocognitive deficits indicating disorders in executive functions, visual memory, attention and social cognition
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DOI: 10.1016/j.pnpbp.2017.06.031
Abstract: The aim of this study was to assess the neurocognitive correlates of affective symptoms in schizophrenia. Towards this end, 40 healthy controls and 80 schizophrenia patients were investigated with six tests of the Cambridge Neuropsychological… read more here.
Keywords: affective symptoms; symptoms schizophrenia; deficits indicating; neurocognitive deficits ... See more keywords
Host Genome Variation is Associated with Neurocognitive Outcome in Survivors of Pediatric Medulloblastoma1
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DOI: 10.1016/j.tranon.2019.03.004
Abstract: Host genome analysis is a promising source of predictive information for long-term morbidity in cancer survivors. However, studies on genetic predictors of long-term outcome, particularly neurocognitive function following chemoradiation in pediatric oncology, are limited. Here,… read more here.
Keywords: outcome; long term; host genome; oncology ... See more keywords