Evaluation of heptelidic acid as a potential inhibitor for tau aggregation-induced Alzheimer's disease and associated neurotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.05.018
Abstract: Tau is a major component of protein plaques in tauopathies, especially Alzheimer's disease (AD). The purpose of the present study is to explore the inhibitory effects of heptelidic acid as a bioactive compound from fungus… read more here.
Keywords: tau; tau fibrillization; alzheimer disease; associated neurotoxicity ... See more keywords
Biomarkers associated with neurotoxicity in adult patients with relapsed or refractory B-ALL (R/R B-ALL) treated with CD19 CAR T cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.3019
Abstract: 3019Background: CD19-specific chimeric antigen receptor (CAR) modified T cells produce high and durable anti-tumor activity, but can be associated with treatment-related toxicities including cytoki... read more here.
Keywords: cd19; neurotoxicity adult; associated neurotoxicity; biomarkers associated ... See more keywords
A systematic framework for predictive biomarkers in immune effector cell-associated neurotoxicity syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2023.1110647
Abstract: Chimeric antigen receptor (CAR)-T cell therapy has revolutionized the management of several life-threatening malignancies, often achieving durable sustained responses. The number of patients treated with this new class of cell-based therapy, along with the number… read more here.
Keywords: predictive biomarkers; cell; cell associated; associated neurotoxicity ... See more keywords
Immunotherapy Associated Neurotoxicity in Pediatric Oncology
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.836452
Abstract: Novel immunotherapies are increasingly being employed in pediatric oncology, both in the upfront and relapsed/refractory settings. Through various mechanisms of action, engagement and activation of the immune system can cause both generalized and disease site-specific… read more here.
Keywords: oncology; immunotherapy associated; pediatric oncology; associated neurotoxicity ... See more keywords