Elevated IL-38 inhibits IL-23R expression and IL-17A production in thyroid-associated ophthalmopathy.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107300
Abstract: IL-23/IL-23R and PGE2/EP2+EP4 have been recognized as crucial signals that promote Th17 differentiation in many autoimmune diseases, including thyroid-associated ophthalmopathy (TAO). However, the interactive role of IL-23R in IL-23/Th17 signaling and PGE2/Th17 signaling has not… read more here.
Keywords: 23r 17a; tao; thyroid associated; pge2 ... See more keywords
Bulbar Conjunctival Microvascular Alterations in Thyroid-Associated Ophthalmopathy Patients with Different Activities
Sign Up to like & getrecommendations! Published in 2021 at "Current Eye Research"
DOI: 10.1080/02713683.2020.1849729
Abstract: ABSTRACT Purpose: To evaluate the morphologic and hemodynamic changes of bulbar conjunctival vessels in thyroid-associated ophthalmopathy (TAO) patients and the correlations with the activity. Methods: Patients diagnosed as TAO with different clinical activity scores (CAS)… read more here.
Keywords: blood flow; tao; thyroid associated; associated ophthalmopathy ... See more keywords
Cytokines in Thyroid-Associated Ophthalmopathy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/2528046
Abstract: Thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' orbitopathy (GO), is a complex autoimmune condition causing visual impairment, disfigurement, and harm to patients' physical and mental health. The pathogenesis of TAO… read more here.
Keywords: cytokines thyroid; thyroid associated; associated ophthalmopathy; immunology ... See more keywords
Detection and Correlation Analysis of Serum Uric Acid in Patients with Thyroid-Associated Ophthalmopathy
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/8406834
Abstract: Purpose To probe the property of serum uric acid in evaluating the activity of patients with thyroid-associated ophthalmopathy. Methods A total of 443 patients with TAO admitted to our hospital from March 2016 to February… read more here.
Keywords: serum uric; associated ophthalmopathy; group; correlation ... See more keywords
Teprotumumab Treatment for Thyroid-Associated Ophthalmopathy
Sign Up to like & getrecommendations! Published in 2020 at "European Thyroid Journal"
DOI: 10.1159/000507992
Abstract: Background: Thyroid-associated ophthalmopathy (TAO), an autoimmune process affecting the tissues surrounding the eye, most commonly develops in individuals with Graves’ disease. It is disfiguring, can cause vision loss, and dramatically lessens the quality of life… read more here.
Keywords: thyroid associated; treatment tao; treatment; teprotumumab treatment ... See more keywords
Looking Beyond Th17 Cells: A Role for Th17.1 Cells in Thyroid-Associated Ophthalmopathy?
Sign Up to like & getrecommendations! Published in 2023 at "Endocrinology"
DOI: 10.1210/endocr/bqad004
Abstract: Thyroid-associated ophthalmopathy, an ordinary extrathyroid syndrome of Graves' disease (GD), is closely associated with immunity. T helper（Th）17, Th1 and Th2 cells in Th lineages are thought to be related to the disease pathogenesis. Recently, there… read more here.
Keywords: th17 cells; associated ophthalmopathy; th17; role th17 ... See more keywords
New advances in understanding thyroid-associated ophthalmopathy and the potential role for insulin-like growth factor-I receptor
Sign Up to like & getrecommendations! Published in 2018 at "F1000Research"
DOI: 10.12688/f1000research.12787.1
Abstract: Thyroid-associated ophthalmopathy (TAO), a localized periocular manifestation of the autoimmune syndrome known as Graves’ disease, remains incompletely understood. Discussions of its pathogenesis are generally focused on the thyrotropin receptor, the proposed role for which is… read more here.
Keywords: thyroid associated; factor receptor; insulin like; growth factor ... See more keywords
The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathy.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2019.07.24
Abstract: Currently, thyroid-associated ophthalmopathy (TAO) lacks effective treatment due to our lack of clarity in its immunopathogenesis. Orbital fibroblasts play a key role in altering inflammation and immune response in TAO, and are considered as the… read more here.
Keywords: thyroid associated; cell mediated; associated ophthalmopathy; role ... See more keywords
MiR-143 Targets IGF-1R to Suppress Autoimmunity in Thyroid-Associated Ophthalmopathy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s339483
Abstract: Objective Thyroid-associated ophthalmopathy (TAO) is an autoimmune disease that involves the remodeling of orbit and periorbital tissues. Thyroid-stimulating hormone receptor (TSHR) and insulin-like growth factor 1 receptor (IGF-1R) may stimulate the activation of autoimmunity in… read more here.
Keywords: tao; associated ophthalmopathy; mir 143; 143 targets ... See more keywords
Adipose/Connective Tissue From Thyroid-Associated Ophthalmopathy Uncovers Interdependence Between Methylation and Disease Pathogenesis: A Genome-Wide Methylation Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.716871
Abstract: In response to pathological stimulation, methylation status conversion of the genome drives changes of cell feature and is able to promote disease development. Yet the role of methylation in the development of thyroid-associated ophthalmopathy (TAO)… read more here.
Keywords: tao; methylation; thyroid associated; tissue ... See more keywords
Research progress and application of artificial intelligence in thyroid associated ophthalmopathy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1124775
Abstract: Thyroid-associated ophthalmopathy (TAO) is a complicated orbitopathy related to dysthyroid, which severely destroys the facial appearance and life quality without medical interference. The diagnosis and management of thyroid-associated ophthalmopathy are extremely intricate, as the number… read more here.
Keywords: thyroid associated; associated ophthalmopathy; artificial intelligence; progress ... See more keywords