Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases.
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DOI: 10.1016/j.jmb.2018.06.048
Abstract: Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. Their dysregulation has been associated with many cancers. We set out to study the catalytic and inhibitory properties of… read more here.
Keywords: associated oxoglutarate; histone lysine; lysine demethylases; cancer ... See more keywords