Common X‐Chromosome Variants Are Associated with Parkinson Disease Risk
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Neurology"
DOI: 10.1002/ana.26051
Abstract: The objective of this study was to identify genetic variants on the X‐chromosome associated with Parkinson disease (PD) risk. read more here.
Keywords: associated parkinson; chromosome; disease risk; parkinson disease ... See more keywords
Role of Lysosomal Gene Variants in Modulating GBA ‐Associated Parkinson's Disease Risk
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DOI: 10.1002/mds.28987
Abstract: To date, variants in the GBA gene represent the most frequent large‐effect genetic factor associated with Parkinson's disease (PD). However, the reason why individuals with the same GBA variant may or may not develop neurodegeneration… read more here.
Keywords: associated parkinson; lysosomal gene; parkinson disease; role lysosomal ... See more keywords
A novel p.L216I mutation in the glucocerebrosidase gene is associated with Parkinson’s disease in Han Chinese patients
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.03.017
Abstract: OBJECTIVES Pathogenic mutations in the glucocerebrosidase (GBA) gene are associated with Parkinson's disease (PD), of which L444P and N370S are the most frequently observed in patients with PD. The aim of this study was to… read more here.
Keywords: gene associated; associated parkinson; chinese patients; han chinese ... See more keywords
Controversy of TMEM230 Associated with Parkinson’s Disease
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DOI: 10.1016/j.neuroscience.2020.11.004
Abstract: Parkinson's disease (PD) is a common neurodegenerative disease with movement disorders including resting tremor, bradykinesia, rigidity, and postural instability. The key pathological features of PD are selective loss of dopaminergic (DA) neurons in substantial nigra… read more here.
Keywords: tmem230 associated; controversy tmem230; associated parkinson; disease ... See more keywords
Can GBA1-Associated Parkinson Disease Be Modeled in the Mouse?
Sign Up to like & getrecommendations! Published in 2019 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2019.05.010
Abstract: Homozygous and heterozygous mutations in GBA1, the gene implicated in Gaucher disease, increase the risk and severity of Parkinson disease (PD). We evaluated the design, phenotype, strengths, and limitations of current GBA1-associated PD mouse models.… read more here.
Keywords: gba1 associated; disease modeled; associated parkinson; modeled mouse ... See more keywords
Exploring the Epigenetic Regulated Modulation of Fibroblast Growth Factor 21 Involvement in High-Fat Diet Associated Parkinson's Disease in Rats.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00659
Abstract: Imbalance in brain glucose metabolism and epigenetic modulation during the disease course of insulin resistance (IR) associated with Parkinson's disease (PD) risk remains a prime concern. Fibroblast growth factor 21 (FGF21), the metabolic hormone, improves… read more here.
Keywords: associated parkinson; disease; modulation; combination ... See more keywords