Detection of LC3‐Associated Phagocytosis (LAP)
Sign Up to like & getrecommendations! Published in 2020 at "Current Protocols in Cell Biology"
DOI: 10.1002/cpcb.104
Abstract: Phagocytes, notably macrophages, are critical sentinels of their environment, patrolling for and eradicating unwanted components. The ability of cells to process extracellular cargo in an appropriate manner is important for both clearance of the cargo… read more here.
Keywords: associated phagocytosis; phagocytosis lap; lc3 associated; phagocytosis ... See more keywords
LAP it up, fuzz ball: a short history of LC3-associated phagocytosis.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2018.09.011
Abstract: LC3-associated phagocytosis (LAP) exists at the crossroads of the two evolutionary pathways of phagocytosis and autophagy. When a phagocyte engulfs an extracellular particle that engages receptor signaling, components of the autophagy machinery and Rubicon are… read more here.
Keywords: lc3 associated; phagocytosis; associated phagocytosis; lap fuzz ... See more keywords
Bioengineered Nanospores Selectively Blocking LC3-Associated Phagocytosis in Tumor-Associated Macrophages Potentiate Antitumor Immunity.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.3c02657
Abstract: Although cytotoxic treatments hold tremendous potential in boosting antitumor immunity, efferocytosis of tumor-associated macrophages (TAMs) could negatively remove apoptotic tumor cells through LC3-associated phagocytosis (LAP), resulting in inefficient tumor antigen presentation and immunosuppressive tumor microenvironment.… read more here.
Keywords: lc3 associated; associated phagocytosis; associated macrophages; tumor ... See more keywords
LC3-associated phagocytosis initiated by integrin ITGAM-ITGB2/Mac-1 enhances immunity to Listeria monocytogenes
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2018.1475816
Abstract: ABSTRACT The macroautophagic/autophagic machinery cannot only target cell-endogenous components but also intracellular pathogenic bacteria such as Listeria monocytogenes. Listeria are targeted both by canonical autophagy and by a noncanonical form of autophagy referred to as… read more here.
Keywords: integrin itgam; lc3 associated; immunity; listeria ... See more keywords
Beyond autophagy: LC3-associated phagocytosis and endocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn1702
Abstract: Noncanonical functions of the autophagy machinery in pathways including LC3-associated phagocytosis and LC3-associated endocytosis have garnered increasing interest in both normal physiology and pathobiology. New discoveries over the past decade of noncanonical uses of the… read more here.
Keywords: beyond autophagy; lc3 associated; lc3; associated phagocytosis ... See more keywords
Control of infection by LC3-associated phagocytosis, CASM, and detection of raised vacuolar pH by the V-ATPase-ATG16L1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn3298
Abstract: The delivery of pathogens to lysosomes for degradation provides an important defense against infection. Degradation is enhanced when LC3 is conjugated to endosomes and phagosomes containing pathogens to facilitate fusion with lysosomes. In phagocytic cells,… read more here.
Keywords: lc3 associated; associated phagocytosis; atpase atg16l1; atpase ... See more keywords
LC3-Associated Phagocytosis (LAP): A Potentially Influential Mediator of Efferocytosis-Related Tumor Progression and Aggressiveness
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.01298
Abstract: One aim of cancer therapies is to induce apoptosis of tumor cells. Efficient removal of the apoptotic cells requires coordinated efforts between the processes of efferocytosis and LC3-associated phagocytosis (LAP). However, this activity has also… read more here.
Keywords: tumor progression; lc3 associated; associated phagocytosis; efferocytosis ... See more keywords
Transcriptomic Changes Predict Metabolic Alterations in LC3 Associated Phagocytosis in Aged Mice.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of molecular sciences"
DOI: 10.3390/ijms24076716
Abstract: LC3b (Map1lc3b) plays an essential role in canonical autophagy and is one of several components of the autophagy machinery that mediates non-canonical autophagic functions. Phagosomes are often associated with lipidated LC3b to promote phagosome maturation… read more here.
Keywords: inflammation; lc3 associated; associated phagocytosis; changes predict ... See more keywords