Metabolites of Vinca Alkaloid Vinblastine: Tubulin Binding and Activation of Nausea-Associated Receptors
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DOI: 10.1021/acsomega.9b00652
Abstract: Vinblastine (VLB) is an antimitotic drug that binds to the vinca site of tubulin. The molecule possesses a high molecular weight and a complex chemical structure with many possibilities of metabolization. Despite advances in drug… read more here.
Keywords: drug; vlb; nausea associated; tubulin ... See more keywords
Evolution of Brain-Expressed Biogenic Amine Receptors into Olfactory Trace Amine-Associated Receptors
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DOI: 10.1093/molbev/msac006
Abstract: Abstract The family of trace amine-associated receptors (TAARs) is distantly related to G protein-coupled biogenic aminergic receptors. TAARs are found in the brain as well as in the olfactory epithelium where they detect biogenic amines.… read more here.
Keywords: associated receptors; brain; trace amine; amine associated ... See more keywords
Trace Amine-Associated Receptors as Novel Therapeutic Targets for Immunomodulatory Disorders
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DOI: 10.3389/fphar.2018.00680
Abstract: Trace amines and their receptors (trace amine-associated receptors; TAARs) are an emerging pharmacological target for the treatment of human disorders. While most studies have focused on their therapeutic potential for neurologic and psychiatric disorders, TAARs… read more here.
Keywords: immunomodulatory disorders; associated receptors; trace amine; amine ... See more keywords
Deregulation of Trace Amine-Associated Receptors (TAAR) Expression and Signaling Mode in Melanoma
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DOI: 10.3390/biom12010114
Abstract: Trace amine-associated receptors (TAARs) interact with amine compounds called “trace amines” which are present in tissues at low concentrations. Recently, TAARs expression in neoplastic tumors was reported. In this study, TAARs expression was analyzed in… read more here.
Keywords: melanoma; associated receptors; expression; trace amine ... See more keywords