Expanding the spectrum of dicer1-associated sarcomas
Sign Up to like & getrecommendations! Published in 2019 at "Modern Pathology"
DOI: 10.1038/s41379-019-0366-x
Abstract: DICER1 syndrome is a hereditary cancer predisposition syndrome caused by deleterious germline DICER1 mutations. Characteristic “hotspot” somatic mutations of DICER1 have been identified in DICER1-associated tumors. With the exception of genitourinary embryonal rhabdomyosarcoma and anaplastic… read more here.
Keywords: sarcoma; dicer1 associated; dicer1; associated sarcomas ... See more keywords
Radiation‐associated sarcomas other than malignant peripheral nerve sheath tumours demonstrate loss of histone H3K27 trimethylation†
Sign Up to like & getrecommendations! Published in 2020 at "Histopathology"
DOI: 10.1111/his.14223
Abstract: Complete loss of histone H3 lysine 27 trimethylation (H3K27me3) has recently emerged as a biomarker for malignant peripheral nerve sheath tumours (MPNST). Loss of H3K27me3 staining has also been reported in post‐radiation MPNST; however, it… read more here.
Keywords: associated sarcomas; malignant peripheral; loss; loss histone ... See more keywords