Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence‐associated secretory phenotype
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12041
Abstract: Abstract A hallmark of senescence is the acquisition of an enhanced secretome comprising inflammatory mediators and tissue remodelling agents – the senescence‐associated secretory phenotype (SASP). Through the SASP, senescent cells are hypothesised to contribute to… read more here.
Keywords: methodology; secretory phenotype; senescence associated; senescence ... See more keywords
Identification of a novel senomorphic agent, avenanthramide C, via the suppression of the senescence-associated secretory phenotype
Sign Up to like & getrecommendations! Published in 2020 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2020.111355
Abstract: Senescent cells are deeply involved in the induction of tissue damage and aging-related diseases. The identification of factors that eliminate senescent cells or inhibit the senescence-associated secretory phenotype (SASP) in these cells is necessary. Here,… read more here.
Keywords: secretory phenotype; senescence associated; senescent cells; associated secretory ... See more keywords
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.03.018
Abstract: Cellular senescence is a state of stable proliferative arrest triggered by damaging signals. Senescent cells persist during aging and promote age-related pathologies via the pro-inflammatory senescence-associated secretory phenotype (SASP), whose regulation depends on environmental factors.… read more here.
Keywords: secretory phenotype; senescence associated; senescent cells; senescence ... See more keywords
A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.02.011
Abstract: A hexanucleotide repeat expansion on chromosome 9 open reading frame 72 (C9orf72) is associated with familial amyotrophic lateral sclerosis (ALS) and a subpopulation of patients with sporadic ALS and frontotemporal dementia. We used inducible pluripotent… read more here.
Keywords: secretory phenotype; dementia; senescence associated; cell cycle ... See more keywords
The variant senescence‐associated secretory phenotype induced by centrosome amplification constitutes a pathway that activates hypoxia‐inducible factor‐1α
Sign Up to like & getrecommendations! Published in 2023 at "Aging Cell"
DOI: 10.1111/acel.13766
Abstract: The senescence‐associated secretory phenotype (SASP) can promote paracrine invasion while suppressing tumour growth, thus generating complex phenotypic outcomes. Likewise, centrosome amplification can induce proliferation arrest yet also facilitate tumour invasion. However, the eventual fate of… read more here.
Keywords: secretory phenotype; associated secretory; amplification; centrosome amplification ... See more keywords
Melatonin regulates PARP1 to control the senescence‐associated secretory phenotype (SASP) in human fetal lung fibroblast cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pineal Research"
DOI: 10.1111/jpi.12405
Abstract: Cellular senescence is an important tumor‐suppressive mechanism. However, acquisition of a senescence‐associated secretory phenotype (SASP) in senescent cells has deleterious effects on the tissue microenvironment and, paradoxically, promotes tumor progression. In a drug screen, we… read more here.
Keywords: secretory phenotype; senescence associated; sasp; associated secretory ... See more keywords
Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Biology and Medicine"
DOI: 10.1177/1535370220943122
Abstract: Cellular senescence has evolved as a protective mechanism to arrest growth of cells with oncogenic potential but is accompanied by the often pathologically deleterious senescence-associated secretory phenotype (SASP). Here we demonstrate an H2O2-dependent functional disruption… read more here.
Keywords: secretory phenotype; senescence associated; sasp; associated secretory ... See more keywords
The role of icIL-1RA in keratinocyte senescence and development of the senescence-associated secretory phenotype
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cell Science"
DOI: 10.1242/jcs.252080
Abstract: ABSTRACT There is compelling evidence that senescent cells, through the senescence-associated secretory phenotype (SASP), can promote malignant transformation and invasion. Interleukin-1 (IL-1) is a key mediator of this cytokine network, but the control of its… read more here.
Keywords: secretory phenotype; senescence associated; senescence; icil 1ra1 ... See more keywords
In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers.
Sign Up to like & getrecommendations! Published in 2023 at "Aging"
DOI: 10.18632/aging.204701
Abstract: In addition to reducing fracture risk, zoledronic acid has been found in some studies to decrease mortality in humans and extend lifespan and healthspan in animals. Because senescent cells accumulate with aging and contribute to… read more here.
Keywords: associated secretory; zoledronic acid; senescence; senescent cells ... See more keywords
Cellular senescence, senescence-associated secretory phenotype, and chronic kidney disease.
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DOI: 10.18632/oncotarget.17327
Abstract: Chronic kidney disease (CKD) is increasingly being accepted as a type of renal ageing. The kidney undergoes age-related alterations in both structure and function. To date, a comprehensive analysis of cellular senescence and senescence-associated secretory… read more here.
Keywords: secretory phenotype; senescence; associated secretory; ckd ... See more keywords
Unique Human and Mouse β-Cell Senescence-Associated Secretory Phenotype (SASP) Reveal Conserved Signaling Pathways and Heterogeneous Factors
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DOI: 10.2337/db20-0553
Abstract: The aging of pancreatic β-cells may undermine their ability to compensate for insulin resistance, leading to the development of type 2 diabetes (T2D). Aging β-cells acquire markers of cellular senescence and develop a senescence-associated secretory… read more here.
Keywords: senescence associated; sasp; senescence; associated secretory ... See more keywords