Hepatocellular Carcinoma in Metabolic Dysfunction-Associated Steatotic Liver Disease
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2024.21019
Abstract: Key Points Question In patients with metabolic dysfunction–associated steatotic liver disease (MASLD), can those at high risk of developing hepatocellular carcinoma (HCC) be identified? Findings This prognostic study used electronic health record data from 1 811 461… read more here.
Keywords: steatotic liver; dysfunction associated; hepatocellular carcinoma; liver disease ... See more keywords
Non‐invasive assessment of hepatic steatosis by ultrasound‐derived fat fraction in individuals at high‐risk for metabolic dysfunction‐associated steatotic liver disease
Sign Up to like & getrecommendations! Published in 2024 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3787
Abstract: Given the increasing number of individuals developing metabolic dysfunction‐associated steatotic liver disease (MASLD) and the low rate of those with progressive liver disease, there is a pressing need to conceive affordable biomarkers to assess MASLD… read more here.
Keywords: dysfunction associated; liver disease; metabolic dysfunction; liver ... See more keywords
Incident heart failure is common and underrecognized in patients with biopsy-proven metabolic dysfunction-associated steatotic liver disease.
Sign Up to like & getrecommendations! Published in 2025 at "European journal of heart failure"
DOI: 10.1002/ejhf.3697
Abstract: Metabolic dysfunction‐associated steatotic liver disease (MASLD) is associated with heart failure (HF), independent of shared risk factors. Our aim was to describe the incidence of HF in patients with biopsy‐proven MASLD. read more here.
Keywords: heart; dysfunction associated; heart failure; metabolic dysfunction ... See more keywords
Cardiovascular risk of metabolic-dysfunction-associated steatotic liver disease in Mexican pediatric population.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of pediatric gastroenterology and nutrition"
DOI: 10.1002/jpn3.70287
Abstract: OBJECTIVE This study examines the association between metabolic-dysfunction-associated steatotic liver disease (MASLD) and cardiovascular risk, focusing on the predictive value of anthropometric, metabolic, and hepatic markers. METHODS A predictive cross-sectional study was conducted in children… read more here.
Keywords: dysfunction associated; risk; metabolic dysfunction; associated steatotic ... See more keywords
Metabolic dysfunction associated steatotic liver disease—Clinicians should not underestimate the role of steatosis
Sign Up to like & getrecommendations! Published in 2024 at "United European Gastroenterology Journal"
DOI: 10.1002/ueg2.12520
Abstract: and longitudinally monitor treatment effects of upcoming therapeutic options like the thyroid receptor beta agonist resmetirom which has recently successfully passed phase 3 development. 13 These tools finally should also predict hepatic and cardiovascular endpoints… read more here.
Keywords: steatotic liver; dysfunction associated; disease clinicians; liver disease ... See more keywords
Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial
Sign Up to like & getrecommendations! Published in 2024 at "Nature Medicine"
DOI: 10.1038/s41591-024-03018-2
Abstract: Retatrutide is a novel triple agonist of the glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1 and glucagon receptors. A 48-week phase 2 obesity study demonstrated weight reductions of 22.8% and 24.2% with retatrutide 8 and 12 mg,… read more here.
Keywords: steatotic liver; dysfunction associated; trial; retatrutide ... See more keywords
Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease
Sign Up to like & getrecommendations! Published in 2024 at "Nature Medicine"
DOI: 10.1038/s41591-024-03283-1
Abstract: Metabolic dysfunction-associated steatotic liver disease (MASLD) exhibits considerable variability in clinical outcomes. Identifying specific phenotypic profiles within MASLD is essential for developing targeted therapeutic strategies. Here we investigated the heterogeneity of MASLD using partitioning around… read more here.
Keywords: disease; associated steatotic; dysfunction associated; metabolic dysfunction ... See more keywords
Abnormal ac4C modification in metabolic dysfunction associated steatotic liver cells
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-024-84564-0
Abstract: The pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear due to the complexity of its etiology. The emerging field of the epitranscriptome has shown significant promise in advancing the understanding of disease pathogenesis… read more here.
Keywords: steatotic liver; dysfunction associated; ac4c modification; metabolic dysfunction ... See more keywords
Metabolic dysfunction-associated steatotic liver disease is associated with androgenetic alopecia in adults with stronger effects in women and unhealthy lifestyles
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-26483-2
Abstract: Androgenetic alopecia (AGA), the most prevalent hair loss type, significantly affects life quality. While androgen excess has been linked to metabolic dysfunction–associated steatotic liver disease (MASLD), their direct association remains underexplored. The cross-sectional investigation enrolled… read more here.
Keywords: steatotic liver; androgenetic alopecia; dysfunction associated; liver disease ... See more keywords
Association of platelet to albumin ratio with metabolic dysfunction-associated steatotic liver disease based on the National Health and Nutrition Survey 2017–2018
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DOI: 10.1038/s41598-025-92837-5
Abstract: The prevalence and incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) are significantly increasing globally, but the index of non-invasive disease is limited. Platelet-albumin ratio(PAR) is a non-invasive biomarker of inflammation, the aim of this… read more here.
Keywords: disease; dysfunction associated; metabolic dysfunction; masld ... See more keywords
Predicting metabolic dysfunction associated steatotic liver disease using explainable machine learning methods
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-96478-6
Abstract: Early and accurate identification of patients at high risk of metabolic dysfunction-associated steatotic liver disease (MASLD) is critical to prevent and improve prognosis potentially. We aimed to develop and validate an explainable prediction model based… read more here.
Keywords: steatotic liver; dysfunction associated; liver disease; model ... See more keywords